Breast cancer: PET imaging of estrogen receptors

M. A. Mintun; M. J. Welch; B. A. Siegel; C. J. Mathias; J. W. Brodack; A. H. McGuire; J. A. Katzenellenbogen

doi:10.1148/radiology.169.1.3262228

Breast cancer: PET imaging of estrogen receptors

M. A. Mintun, M. J. Welch, B. A. Siegel, C. J. Mathias, J. W. Brodack, A. H. McGuire, J. A. Katzenellenbogen

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Abstract

Thirteen patients with primary breast masses were studied with positron emission tomography (PET) and 16α-[fluorine-18]-fluoroestradiol-17β. PET images demonstrated uptake of the labeled estrogen analog at sites of primary carcinomas and in several foci of axillary lymph node metastases, as well as in one distant metastatic site. There was excellent correlation between uptake within the primary tumor measured on the PET images and the tumor estrogen-receptor concentration measured in vitro after excision (r = .96). This technique may provide an in vivo method of assessing estrogen receptors in primary and metastatic breast cancers and thus guide management of this disease with antiestrogen chemotherapy.

Original language	English
Pages (from-to)	45-48
Number of pages	4
Journal	Radiology
Volume	169
Issue number	1
DOIs	https://doi.org/10.1148/radiology.169.1.3262228
State	Published - 1988

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title = "Breast cancer: PET imaging of estrogen receptors",

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year = "1988",

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TY - JOUR

T1 - Breast cancer

T2 - PET imaging of estrogen receptors

AU - Mintun, M. A.

AU - Welch, M. J.

AU - Siegel, B. A.

AU - Mathias, C. J.

AU - Brodack, J. W.

AU - McGuire, A. H.

AU - Katzenellenbogen, J. A.

PY - 1988

Y1 - 1988

N2 - Thirteen patients with primary breast masses were studied with positron emission tomography (PET) and 16α-[fluorine-18]-fluoroestradiol-17β. PET images demonstrated uptake of the labeled estrogen analog at sites of primary carcinomas and in several foci of axillary lymph node metastases, as well as in one distant metastatic site. There was excellent correlation between uptake within the primary tumor measured on the PET images and the tumor estrogen-receptor concentration measured in vitro after excision (r = .96). This technique may provide an in vivo method of assessing estrogen receptors in primary and metastatic breast cancers and thus guide management of this disease with antiestrogen chemotherapy.

AB - Thirteen patients with primary breast masses were studied with positron emission tomography (PET) and 16α-[fluorine-18]-fluoroestradiol-17β. PET images demonstrated uptake of the labeled estrogen analog at sites of primary carcinomas and in several foci of axillary lymph node metastases, as well as in one distant metastatic site. There was excellent correlation between uptake within the primary tumor measured on the PET images and the tumor estrogen-receptor concentration measured in vitro after excision (r = .96). This technique may provide an in vivo method of assessing estrogen receptors in primary and metastatic breast cancers and thus guide management of this disease with antiestrogen chemotherapy.

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SN - 0033-8419

VL - 169

SP - 45

EP - 48

JO - Radiology

JF - Radiology

IS - 1

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Breast cancer: PET imaging of estrogen receptors

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