TY - JOUR
T1 - BrainWAVE
T2 - A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species
AU - Attokaren, Matthew K.
AU - Jeong, Nuri
AU - Blanpain, Lou
AU - Paulson, Abigail L.
AU - Garza, Kristie M.
AU - Borron, Ben
AU - Walelign, Michael
AU - Willie, Jon
AU - Singer, Annabelle C.
N1 - Funding Information:
A.C.S. was supported by the Packard Foundation, the National Institutes of Health (NIH)-National Institute of Neurological Disorders and Stroke Grant R01 NS109226, the NIH National Institute of Aging Grant RF1AG078736-01, McCamish Foundation, Friends and Alumni of Georgia Tech, and the Lane Family. N.J. was supported by the Michael Kuhar Neuroscience Research Fellowship. K.M.G. was supported by the NIH Grant R01 NS109226-S1. A.L.P. was supported by the NIH National Research Service Award Grant 5F31AG066410, the NIH Grant T32 NS007480-18, Fulton County Elder Health Science Fellowship, Wright Family, and J. Norman and Rosalyn Wells Fellowship. B.B. was supported by the Georgia Tech Presidential Undergraduate Research Award.
Publisher Copyright:
© 2023 Attokaren et al.
PY - 2023/2
Y1 - 2023/2
N2 - Rhythmic neural activity, which coordinates brain regions and neurons to achieve multiple brain functions, is impaired in many diseases. Despite the therapeutic potential of driving brain rhythms, methods to noninvasively target deep brain regions are limited. Accordingly, we recently introduced a noninvasive stimulation approach using flickering lights and sounds (“flicker”). Flicker drives rhythmic activity in deep and superficial brain regions. Gamma flicker spurs immune function, clears pathogens, and rescues memory performance in mice with amyloid pathology. Here, we present substantial improvements to this approach that is flexible, user-friendly, and generalizable across multiple experimental settings and species. We present novel opensource methods for flicker stimulation across rodents and humans. We demonstrate rapid, cross-species induction of rhythmic activity without behavioral confounds in multiple settings from electrophysiology to neuroimaging. This flicker approach provides an exceptional opportunity to discover the therapeutic effects of brain rhythms across scales and species.
AB - Rhythmic neural activity, which coordinates brain regions and neurons to achieve multiple brain functions, is impaired in many diseases. Despite the therapeutic potential of driving brain rhythms, methods to noninvasively target deep brain regions are limited. Accordingly, we recently introduced a noninvasive stimulation approach using flickering lights and sounds (“flicker”). Flicker drives rhythmic activity in deep and superficial brain regions. Gamma flicker spurs immune function, clears pathogens, and rescues memory performance in mice with amyloid pathology. Here, we present substantial improvements to this approach that is flexible, user-friendly, and generalizable across multiple experimental settings and species. We present novel opensource methods for flicker stimulation across rodents and humans. We demonstrate rapid, cross-species induction of rhythmic activity without behavioral confounds in multiple settings from electrophysiology to neuroimaging. This flicker approach provides an exceptional opportunity to discover the therapeutic effects of brain rhythms across scales and species.
KW - brain oscillations
KW - brain stimulation
KW - entrainment
KW - flicker
KW - noninvasive deep brain modulation
KW - sensory stimulation
UR - http://www.scopus.com/inward/record.url?scp=85148703499&partnerID=8YFLogxK
U2 - 10.1523/ENEURO.0257-22.2022
DO - 10.1523/ENEURO.0257-22.2022
M3 - Article
C2 - 36754625
AN - SCOPUS:85148703499
SN - 2373-2822
VL - 10
JO - eNeuro
JF - eNeuro
IS - 2
M1 - ENEURO.0257-22.2022
ER -