TY - JOUR
T1 - Brain/MINDS beyond human brain MRI project
T2 - A protocol for multi-level harmonization across brain disorders throughout the lifespan
AU - Brain/MINDS Beyond Human Brain MRI Group
AU - Koike, Shinsuke
AU - Tanaka, Saori C.
AU - Okada, Tomohisa
AU - Aso, Toshihiko
AU - Yamashita, Ayumu
AU - Yamashita, Okito
AU - Asano, Michiko
AU - Maikusa, Norihide
AU - Morita, Kentaro
AU - Okada, Naohiro
AU - Fukunaga, Masaki
AU - Uematsu, Akiko
AU - Togo, Hiroki
AU - Miyazaki, Atsushi
AU - Murata, Katsutoshi
AU - Urushibata, Yuta
AU - Autio, Joonas
AU - Ose, Takayuki
AU - Yoshimoto, Junichiro
AU - Araki, Toshiyuki
AU - Glasser, Matthew F.
AU - Van Essen, David C.
AU - Maruyama, Megumi
AU - Sadato, Norihiro
AU - Kawato, Mitsuo
AU - Kasai, Kiyoto
AU - Okamoto, Yasumasa
AU - Hanakawa, Takashi
AU - Hayashi, Takuya
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2021/1
Y1 - 2021/1
N2 - Psychiatric and neurological disorders are afflictions of the brain that can affect individuals throughout their lifespan. Many brain magnetic resonance imaging (MRI) studies have been conducted; however, imaging-based biomarkers are not yet well established for diagnostic and therapeutic use. This article describes an outline of the planned study, the Brain/MINDS Beyond human brain MRI project (BMB-HBM, FY2018 ~ FY2023), which aims to establish clinically-relevant imaging biomarkers with multi-site harmonization by collecting data from healthy traveling subjects (TS) at 13 research sites. Collection of data in psychiatric and neurological disorders across the lifespan is also scheduled at 13 sites, whereas designing measurement procedures, developing and analyzing neuroimaging protocols, and databasing are done at three research sites. A high-quality scanning protocol, Harmonization Protocol (HARP), was established for five high-quality 3 T scanners to obtain multimodal brain images including T1 and T2-weighted, resting-state and task functional and diffusion-weighted MRI. Data are preprocessed and analyzed using approaches developed by the Human Connectome Project. Preliminary results in 30 TS demonstrated cortical thickness, myelin, functional connectivity measures are comparable across 5 scanners, suggesting sensitivity to subject-specific connectome. A total of 75 TS and more than two thousand patients with various psychiatric and neurological disorders are scheduled to participate in the project, allowing a mixed model statistical harmonization. The HARP protocols are publicly available online, and all the imaging, demographic and clinical information, harmonizing database will also be made available by 2024. To the best of our knowledge, this is the first project to implement a prospective, multi-level harmonization protocol with multi-site TS data. It explores intractable brain disorders across the lifespan and may help to identify the disease-specific pathophysiology and imaging biomarkers for clinical practice.
AB - Psychiatric and neurological disorders are afflictions of the brain that can affect individuals throughout their lifespan. Many brain magnetic resonance imaging (MRI) studies have been conducted; however, imaging-based biomarkers are not yet well established for diagnostic and therapeutic use. This article describes an outline of the planned study, the Brain/MINDS Beyond human brain MRI project (BMB-HBM, FY2018 ~ FY2023), which aims to establish clinically-relevant imaging biomarkers with multi-site harmonization by collecting data from healthy traveling subjects (TS) at 13 research sites. Collection of data in psychiatric and neurological disorders across the lifespan is also scheduled at 13 sites, whereas designing measurement procedures, developing and analyzing neuroimaging protocols, and databasing are done at three research sites. A high-quality scanning protocol, Harmonization Protocol (HARP), was established for five high-quality 3 T scanners to obtain multimodal brain images including T1 and T2-weighted, resting-state and task functional and diffusion-weighted MRI. Data are preprocessed and analyzed using approaches developed by the Human Connectome Project. Preliminary results in 30 TS demonstrated cortical thickness, myelin, functional connectivity measures are comparable across 5 scanners, suggesting sensitivity to subject-specific connectome. A total of 75 TS and more than two thousand patients with various psychiatric and neurological disorders are scheduled to participate in the project, allowing a mixed model statistical harmonization. The HARP protocols are publicly available online, and all the imaging, demographic and clinical information, harmonizing database will also be made available by 2024. To the best of our knowledge, this is the first project to implement a prospective, multi-level harmonization protocol with multi-site TS data. It explores intractable brain disorders across the lifespan and may help to identify the disease-specific pathophysiology and imaging biomarkers for clinical practice.
KW - HCP-style brain imaging
KW - Harmonization protocol
KW - Multi-site study
KW - Neurological disorders
KW - Psychiatric disorders
KW - Traveling subjects
UR - http://www.scopus.com/inward/record.url?scp=85105985213&partnerID=8YFLogxK
U2 - 10.1016/j.nicl.2021.102600
DO - 10.1016/j.nicl.2021.102600
M3 - Article
C2 - 33741307
AN - SCOPUS:85105985213
SN - 2213-1582
VL - 30
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 102600
ER -