Brain structure in sagittal craniosynostosis

Beatriz Paniagua, Sunghyung Kim, Mahmoud Moustapha, Martin Styner, Heather Cody-Hazlett, Rachel Gimple-Smith, Ashley Rumple, Joseph Piven, John Gilmore, Gary Skolnick, Kamlesh Patel

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Scopus citations


Craniosynostosis, the premature fusion of one or more cranial sutures, leads to grossly abnormal head shapes and pressure elevations within the brain caused by these deformities. To date, accepted treatments for craniosynostosis involve improving surgical skull shape aesthetics. However, the relationship between improved head shape and brain structure after surgery has not been yet established. Typically, clinical standard care involves the collection of diagnostic medical computed tomography (CT) imaging to evaluate the fused sutures and plan the surgical treatment. CT is known to provide very good reconstructions of the hard tissues in the skull but it fails to acquire good soft brain tissue contrast. This study intends to use magnetic resonance imaging to evaluate brain structure in a small dataset of sagittal craniosynostosis patients and thus quantify the effects of surgical intervention in overall brain structure. Very importantly, these effects are to be contrasted with normative shape, volume and brain structure databases. The work presented here wants to address gaps in clinical knowledge in craniosynostosis focusing on understanding the changes in brain volume and shape secondary to surgery, and compare those with normally developing children. This initial pilot study has the potential to add significant quality to the surgical care of a vulnerable patient population in whom we currently have limited understanding of brain developmental outcomes.

Original languageEnglish
Title of host publicationMedical Imaging 2017
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
EditorsBarjor Gimi, Andrzej Krol
ISBN (Electronic)9781510607194
StatePublished - 2017
EventMedical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging - Orlando, United States
Duration: Feb 12 2017Feb 14 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging
Country/TerritoryUnited States


  • Brain Tissue segmentation
  • Computer Assisted Intervention Planning
  • Full vault reconstructive surgery
  • Osteoarthritis
  • Sagittal craniosynostosis
  • Statistical Shape Analysis


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