‘Brain-specific’ benzodiazepine receptors are localized in the inner plexiform layer of rat retina

Phil Soklnick, Steven Paul, Martin Zatz, Robert Eskay

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Saturable, high affinity binding sites of [3H]diazepam have recently been characterized in rat brain. A significant component of this binding was determined to occur to a population of receptors which is pharmacologically similar to receptors present in mammalian brain and spinal cord. Neonatal treatment of rats with monosodium glutamate (MSG), intraocular administration of kainic acid, and the use of pink-eyed, tan-hooded (PETH) rats with a genetic retinopathy (degeneration of photoreceptor cells) suggests that these ‘brain-type’ receptors are highly localized on neuronal elements of the inner plexiform layer and/or ganglion cells.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalEuropean Journal of Pharmacology
Volume66
Issue number1
DOIs
StatePublished - Jan 1 1980

Keywords

  • Benzodiazepine receptors
  • Kainic acid
  • MSG
  • PETH rat
  • Retina

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