Brain Permeability of Water

Marcus E. Raichle; John O. Eichling; Robert L. Grubb

doi:10.1001/archneur.1974.00490340047010

Brain Permeability of Water

Marcus E. Raichle
, John O. Eichling
, Robert L. Grubb

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

The equilibration of labeled water (H₂ ¹⁵O) with the exchangeable water pool of brain was examined during a single capillary transit. The labeled water did not equilibrate freely when cerebral blood flow (CBF) exceeded 20 (ml/100 gm)/min in the rhesus monkey. At normal CBF [.50 (ml/100 gm)/min] only 90% of the injected bolus freely equilibrated with brain. This value progressively declined as CBF increased.

Original language	English
Pages (from-to)	319-321
Number of pages	3
Journal	Archives of neurology
Volume	30
Issue number	4
DOIs	https://doi.org/10.1001/archneur.1974.00490340047010
State	Published - Apr 1974

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10.1001/archneur.1974.00490340047010

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@article{9f136249152e4c02968b416f299cecec,

title = "Brain Permeability of Water",

abstract = "The equilibration of labeled water (H2 15O) with the exchangeable water pool of brain was examined during a single capillary transit. The labeled water did not equilibrate freely when cerebral blood flow (CBF) exceeded 20 (ml/100 gm)/min in the rhesus monkey. At normal CBF [.50 (ml/100 gm)/min] only 90\% of the injected bolus freely equilibrated with brain. This value progressively declined as CBF increased.",

author = "Raichle, \{Marcus E.\} and Eichling, \{John O.\} and Grubb, \{Robert L.\}",

note = "Funding Information: ThisinvestigationwassupportedbyPublic HealthServicegrant5POI HL13851; by research grant RR 00396 from the Division of Research ResourcesoftheNationalInstitutesofHealth, and byTeacher-Investigatoraward 1 Fll NS11059(Dr.Raichle)andgrant5POINSO6833 fromtheNationalInstituteofNeurologicalDis¬ easesandStroke.",

year = "1974",

month = apr,

doi = "10.1001/archneur.1974.00490340047010",

language = "English",

volume = "30",

pages = "319--321",

journal = "Archives of neurology",

issn = "0003-9942",

number = "4",

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TY - JOUR

T1 - Brain Permeability of Water

AU - Raichle, Marcus E.

AU - Eichling, John O.

AU - Grubb, Robert L.

N1 - Funding Information: ThisinvestigationwassupportedbyPublic HealthServicegrant5POI HL13851; by research grant RR 00396 from the Division of Research ResourcesoftheNationalInstitutesofHealth, and byTeacher-Investigatoraward 1 Fll NS11059(Dr.Raichle)andgrant5POINSO6833 fromtheNationalInstituteofNeurologicalDis¬ easesandStroke.

PY - 1974/4

Y1 - 1974/4

N2 - The equilibration of labeled water (H2 15O) with the exchangeable water pool of brain was examined during a single capillary transit. The labeled water did not equilibrate freely when cerebral blood flow (CBF) exceeded 20 (ml/100 gm)/min in the rhesus monkey. At normal CBF [.50 (ml/100 gm)/min] only 90% of the injected bolus freely equilibrated with brain. This value progressively declined as CBF increased.

AB - The equilibration of labeled water (H2 15O) with the exchangeable water pool of brain was examined during a single capillary transit. The labeled water did not equilibrate freely when cerebral blood flow (CBF) exceeded 20 (ml/100 gm)/min in the rhesus monkey. At normal CBF [.50 (ml/100 gm)/min] only 90% of the injected bolus freely equilibrated with brain. This value progressively declined as CBF increased.

UR - https://www.scopus.com/pages/publications/0016211098

U2 - 10.1001/archneur.1974.00490340047010

DO - 10.1001/archneur.1974.00490340047010

M3 - Article

C2 - 4206076

AN - SCOPUS:0016211098

SN - 0003-9942

VL - 30

SP - 319

EP - 321

JO - Archives of neurology

JF - Archives of neurology

IS - 4

ER -

Brain Permeability of Water

Abstract

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