Brain Permeability of Water

Marcus E. Raichle, John O. Eichling, Robert L. Grubb

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


The equilibration of labeled water (H2 15O) with the exchangeable water pool of brain was examined during a single capillary transit. The labeled water did not equilibrate freely when cerebral blood flow (CBF) exceeded 20 (ml/100 gm)/min in the rhesus monkey. At normal CBF [.50 (ml/100 gm)/min] only 90% of the injected bolus freely equilibrated with brain. This value progressively declined as CBF increased.

Original languageEnglish
Pages (from-to)319-321
Number of pages3
JournalArchives of neurology
Issue number4
StatePublished - Apr 1974


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