TY - JOUR
T1 - Brain Perfusion Change in Patients with Mild Cognitive Impairment After 12 Months of Aerobic Exercise Training
AU - Thomas, Binu P.
AU - Tarumi, Takashi
AU - Sheng, Min
AU - Tseng, Benjamin
AU - Womack, Kyle B.
AU - Cullum, C. Munro
AU - Rypma, Bart
AU - Zhang, Rong
AU - Lu, Hanzhang
N1 - Publisher Copyright:
© 2024 IOS Press. All rights reserved.
PY - 2024
Y1 - 2024
N2 - Aerobic exercise (AE) has recently received increasing attention in the prevention of Alzheimer's disease (AD). There is some evidence that it can improve neurocognitive function in elderly individuals. However, the mechanism of these improvements is not completely understood. In this prospective clinical trial, thirty amnestic mild cognitive impairment participants were enrolled into two groups and underwent 12 months of intervention. One group (n = 15) performed AE training (8M/7F, age = 66.4 years), whereas the other (n = 15) performed stretch training (8M/7F, age = 66.1 years) as a control intervention. Both groups performed 25-30 minutes training, 3 times per week. Frequency and duration were gradually increasedovertime.Twelve-monthAEtrainingimprovedcardiorespiratoryfitness(p = 0.04)andmemoryfunction(p = 0.004). Cerebral blood flow (CBF) was measured at pre- and post-training using pseudo-continuous-arterial-spin-labeling MRI. Relative to the stretch group, the AE group displayed a training-related increase in CBF in the anterior cingulate cortex (p = 0.016). Furthermore, across individuals, the extent of memory improvement was associated with CBF increases in anterior cingulate cortex and adjacent prefrontal cortex (voxel-wise p < 0.05). In contrast, AE resulted in a decrease in CBF of the posterior cingulate cortex, when compared to the stretch group (p = 0.01). These results suggest that salutary effects of AE in AD may be mediated by redistribution of blood flow and neural activity in AD-sensitive regions of brain.
AB - Aerobic exercise (AE) has recently received increasing attention in the prevention of Alzheimer's disease (AD). There is some evidence that it can improve neurocognitive function in elderly individuals. However, the mechanism of these improvements is not completely understood. In this prospective clinical trial, thirty amnestic mild cognitive impairment participants were enrolled into two groups and underwent 12 months of intervention. One group (n = 15) performed AE training (8M/7F, age = 66.4 years), whereas the other (n = 15) performed stretch training (8M/7F, age = 66.1 years) as a control intervention. Both groups performed 25-30 minutes training, 3 times per week. Frequency and duration were gradually increasedovertime.Twelve-monthAEtrainingimprovedcardiorespiratoryfitness(p = 0.04)andmemoryfunction(p = 0.004). Cerebral blood flow (CBF) was measured at pre- and post-training using pseudo-continuous-arterial-spin-labeling MRI. Relative to the stretch group, the AE group displayed a training-related increase in CBF in the anterior cingulate cortex (p = 0.016). Furthermore, across individuals, the extent of memory improvement was associated with CBF increases in anterior cingulate cortex and adjacent prefrontal cortex (voxel-wise p < 0.05). In contrast, AE resulted in a decrease in CBF of the posterior cingulate cortex, when compared to the stretch group (p = 0.01). These results suggest that salutary effects of AE in AD may be mediated by redistribution of blood flow and neural activity in AD-sensitive regions of brain.
KW - Aerobic exercise training
KW - Alzheimer's disease
KW - amnestic mild cognitive impairment
KW - anterior cingulate cortex
KW - cerebral blood flow
KW - posterior cingulate cortex
KW - stretch training
UR - http://www.scopus.com/inward/record.url?scp=85185260987&partnerID=8YFLogxK
U2 - 10.3233/AIAD230068
DO - 10.3233/AIAD230068
M3 - Article
AN - SCOPUS:85185260987
SN - 2210-5727
VL - 11
SP - 3
EP - 18
JO - Advances in Alzheimer's Disease
JF - Advances in Alzheimer's Disease
ER -