Brain oxygen utilization measured with oxygen-15 radiotracers and Positron emission tomography: Generation of metabolic images

P. Herscovitch; M. A. Mintun; M. E. Raichle

Brain oxygen utilization measured with oxygen-15 radiotracers and Positron emission tomography: Generation of metabolic images

P. Herscovitch, M. A. Mintun, M. E. Raichle

Research output: Contribution to journal › Article › peer-review

Abstract

We recently described a PET method for the measurement of local brain tissue oxygen extraction (E) and the local cerebral metabolic rate for oxygen (CMRO₂) using ¹⁵O-labeled radiotracers. The equation for the calculation of E from measured PET data is mathematically complex and its direct application in the generation of PET images of either E or the CMRO₂ on a pixel-by-pixel basis is computationally burdensome. We describe a simplification of this equation which permits the efficient generation of quantitative images.

Original language	English
Pages (from-to)	416-417
Number of pages	2
Journal	Journal of Nuclear Medicine
Volume	26
Issue number	4
State	Published - 1985

Cite this

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abstract = "We recently described a PET method for the measurement of local brain tissue oxygen extraction (E) and the local cerebral metabolic rate for oxygen (CMRO2) using 15O-labeled radiotracers. The equation for the calculation of E from measured PET data is mathematically complex and its direct application in the generation of PET images of either E or the CMRO2 on a pixel-by-pixel basis is computationally burdensome. We describe a simplification of this equation which permits the efficient generation of quantitative images.",

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AU - Mintun, M. A.

AU - Raichle, M. E.

PY - 1985

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AB - We recently described a PET method for the measurement of local brain tissue oxygen extraction (E) and the local cerebral metabolic rate for oxygen (CMRO2) using 15O-labeled radiotracers. The equation for the calculation of E from measured PET data is mathematically complex and its direct application in the generation of PET images of either E or the CMRO2 on a pixel-by-pixel basis is computationally burdensome. We describe a simplification of this equation which permits the efficient generation of quantitative images.

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Brain oxygen utilization measured with oxygen-15 radiotracers and Positron emission tomography: Generation of metabolic images

Abstract

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