Brain neurotensin, psychostimulants, and stress - emphasis on neuroanatomical substrates

Stefanie Geisler, Anne Bérod, Daniel S. Zahm, William Rostène

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations


Neurotensin (NT) is a peptide that is widely distributed throughout the brain. NT is involved in locomotion, reward, stress and pain modulation, and in the pathophysiology of drug addiction and depression. In its first part this review brings together relevant literature about the neuroanatomy of NT and its receptors. The second part focuses on functional-anatomical interactions between NT, the mesotelencephalic dopamine system and structures targeted by dopaminergic projections. Finally, recent data about the actions of NT in processes underlying behavioral sensitization to psychostimulant drugs and the involvement of NT in the regulation of the hypothalamo-pituitary-adrenal gland axis are considered.

Original languageEnglish
Pages (from-to)2364-2384
Number of pages21
Issue number10
StatePublished - Oct 2006


  • Amphetamine
  • Corticotrophin-releasing hormone
  • Dopamine
  • Hypothalamo-pituitary-adrenal axis
  • Neuroanatomy
  • Receptors


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