Brain neurotensin, psychostimulants, and stress - emphasis on neuroanatomical substrates

Stefanie Geisler; Anne Bérod; Daniel S. Zahm; William Rostène

doi:10.1016/j.peptides.2006.03.037

Brain neurotensin, psychostimulants, and stress - emphasis on neuroanatomical substrates

Stefanie Geisler, Anne Bérod, Daniel S. Zahm, William Rostène

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

Neurotensin (NT) is a peptide that is widely distributed throughout the brain. NT is involved in locomotion, reward, stress and pain modulation, and in the pathophysiology of drug addiction and depression. In its first part this review brings together relevant literature about the neuroanatomy of NT and its receptors. The second part focuses on functional-anatomical interactions between NT, the mesotelencephalic dopamine system and structures targeted by dopaminergic projections. Finally, recent data about the actions of NT in processes underlying behavioral sensitization to psychostimulant drugs and the involvement of NT in the regulation of the hypothalamo-pituitary-adrenal gland axis are considered.

Original language	English
Pages (from-to)	2364-2384
Number of pages	21
Journal	Peptides
Volume	27
Issue number	10
DOIs	https://doi.org/10.1016/j.peptides.2006.03.037
State	Published - Oct 2006

Keywords

Amphetamine
Corticotrophin-releasing hormone
Dopamine
Hypothalamo-pituitary-adrenal axis
Neuroanatomy
Receptors

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10.1016/j.peptides.2006.03.037

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title = "Brain neurotensin, psychostimulants, and stress - emphasis on neuroanatomical substrates",

abstract = "Neurotensin (NT) is a peptide that is widely distributed throughout the brain. NT is involved in locomotion, reward, stress and pain modulation, and in the pathophysiology of drug addiction and depression. In its first part this review brings together relevant literature about the neuroanatomy of NT and its receptors. The second part focuses on functional-anatomical interactions between NT, the mesotelencephalic dopamine system and structures targeted by dopaminergic projections. Finally, recent data about the actions of NT in processes underlying behavioral sensitization to psychostimulant drugs and the involvement of NT in the regulation of the hypothalamo-pituitary-adrenal gland axis are considered.",

keywords = "Amphetamine, Corticotrophin-releasing hormone, Dopamine, Hypothalamo-pituitary-adrenal axis, Neuroanatomy, Receptors",

author = "Stefanie Geisler and Anne B{\'e}rod and Zahm, {Daniel S.} and William Rost{\`e}ne",

note = "Funding Information: The authors gratefully acknowledge the support by USPHS grant DA 15207. This work was partly supported by INSERM. Sanofi kindly provided the authors with SR 48692.",

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AU - Geisler, Stefanie

AU - Bérod, Anne

AU - Zahm, Daniel S.

AU - Rostène, William

N1 - Funding Information: The authors gratefully acknowledge the support by USPHS grant DA 15207. This work was partly supported by INSERM. Sanofi kindly provided the authors with SR 48692.

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AB - Neurotensin (NT) is a peptide that is widely distributed throughout the brain. NT is involved in locomotion, reward, stress and pain modulation, and in the pathophysiology of drug addiction and depression. In its first part this review brings together relevant literature about the neuroanatomy of NT and its receptors. The second part focuses on functional-anatomical interactions between NT, the mesotelencephalic dopamine system and structures targeted by dopaminergic projections. Finally, recent data about the actions of NT in processes underlying behavioral sensitization to psychostimulant drugs and the involvement of NT in the regulation of the hypothalamo-pituitary-adrenal gland axis are considered.

KW - Amphetamine

KW - Corticotrophin-releasing hormone

KW - Dopamine

KW - Hypothalamo-pituitary-adrenal axis

KW - Neuroanatomy

KW - Receptors

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DO - 10.1016/j.peptides.2006.03.037

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EP - 2384

JO - Peptides

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Brain neurotensin, psychostimulants, and stress - emphasis on neuroanatomical substrates

Abstract

Keywords

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