3 Scopus citations


Age-dependent changes in brain metabolism may influence the response to and tolerance of secondary insults, potentially affecting outcomes. More complete characterization of brain metabolism across the clinical trajectory of severe pediatric TBI is needed to improve our ability to measure and better mitigate the impact of secondary insults. Better management of secondary insults will impact clinical care and the probability of success of future neuroprotective clinical trials. Improved bedside monitoring and imaging technologies will be required to achieve these goals. Effective and sustained integration of brain metabolism information into the pediatric critical care setting will be equally challenging and important.

Original languageEnglish
Pages (from-to)1719-1726
Number of pages8
JournalChild's Nervous System
Issue number10
StatePublished - Oct 1 2017


  • Brain metabolism
  • Secondary injury
  • Traumatic brain injury


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