TY - JOUR
T1 - Brain Levels of Neuron‐Specific and Nonneuronal Enolase in Huntington's Disease
AU - Marangos, P. J.
AU - Paul, S. M.
PY - 1981/11
Y1 - 1981/11
N2 - Abstract— Levels of the cell‐specific brain isoenzymes of enolase were determined in basal ganglia and cerebral cortical tissue of Huntington's disease and age‐ and sex‐matched control brain. Neuron‐specific enolase (NSE) levels are decreased an average of 45% in basal ganglia from patients with Huntington's disease whereas the glial‐specific form of enolase, nonneuronal enolase (NNE), is not significantly altered. In contrast, levels of NSE in cerebral cortical tissue from Huntington's disease patients remains unchanged in comparison with controls whereas NNE levels are significantly increased. NNE and NSE levels appear to be specific biochemical indicators of glial and neuronal cell number and viability. Levels of these cell‐specific isoenzymes may therefore prove useful in quantitating neuropathological changes in various neurological disorders.
AB - Abstract— Levels of the cell‐specific brain isoenzymes of enolase were determined in basal ganglia and cerebral cortical tissue of Huntington's disease and age‐ and sex‐matched control brain. Neuron‐specific enolase (NSE) levels are decreased an average of 45% in basal ganglia from patients with Huntington's disease whereas the glial‐specific form of enolase, nonneuronal enolase (NNE), is not significantly altered. In contrast, levels of NSE in cerebral cortical tissue from Huntington's disease patients remains unchanged in comparison with controls whereas NNE levels are significantly increased. NNE and NSE levels appear to be specific biochemical indicators of glial and neuronal cell number and viability. Levels of these cell‐specific isoenzymes may therefore prove useful in quantitating neuropathological changes in various neurological disorders.
KW - Huntington's disease.
KW - Neuron‐specific enolase
KW - Nonneuronal enolase
UR - http://www.scopus.com/inward/record.url?scp=0019806619&partnerID=8YFLogxK
U2 - 10.1111/j.1471-4159.1981.tb04687.x
DO - 10.1111/j.1471-4159.1981.tb04687.x
M3 - Article
C2 - 6457899
AN - SCOPUS:0019806619
SN - 0022-3042
VL - 37
SP - 1338
EP - 1340
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
IS - 5
ER -