Brain growth in congenital heart disease from prenatal environment to adulthood

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Over the past several decades, improved survival for children with moderate-severe congenital heart defects has led to heightened recognition of the long-term neurodevelopmental sequelae associated with this diagnosis. Magnetic resonance imaging studies have identified that abnormal brain growth is common in congenital heart disease and is associated with impaired cognitive and motor outcomes. Deficits in brain growth begin prenatally, progress along an altered trajectory after birth, and continue to be present in adolescents and adults with congenital heart disease. Global disturbances in cerebral white and gray matter development contribute to impaired brain growth and result from altered prenatal cardiac physiology, postnatal hemodynamic changes, surgical and perioperative clinical factors, and genetic variants.

Original languageEnglish
Title of host publicationDiagnosis, Management and Modeling of Neurodevelopmental Disorders
Subtitle of host publicationThe Neuroscience of Development
Number of pages10
ISBN (Electronic)9780128179888
ISBN (Print)9780128179895
StatePublished - Jan 1 2021


  • Brain growth
  • Brain injury
  • Congenital heart disease
  • Magnetic resonance imaging
  • Neurodevelopment


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