TY - JOUR
T1 - Brain damage, stress, and life span
T2 - An experimental study
AU - Wozniak, D.
AU - Finger, S.
AU - Blumenthal, H.
AU - Poland, R.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - Mice received frontal pole transections or sham operations, and approximately half in each group experienced cold stress five times throughout their lives. On two occasions certain selected animals were subjected to cold + restraint stress. Neither the brain lesions nor the cold stress affected life span. The stressors, however, were effective in temporarily elevating serum corticosterone levels and, in the case of cold + restraint, producing gastric stress erosions. A significant partial correlation between stress and cause of death was found. This effect appeared to be due primarily to reticulum cell sarcomas metastasizing to the lung (pulmonary tumors) with much greater frequency among animals exposed to stress.
AB - Mice received frontal pole transections or sham operations, and approximately half in each group experienced cold stress five times throughout their lives. On two occasions certain selected animals were subjected to cold + restraint stress. Neither the brain lesions nor the cold stress affected life span. The stressors, however, were effective in temporarily elevating serum corticosterone levels and, in the case of cold + restraint, producing gastric stress erosions. A significant partial correlation between stress and cause of death was found. This effect appeared to be due primarily to reticulum cell sarcomas metastasizing to the lung (pulmonary tumors) with much greater frequency among animals exposed to stress.
UR - http://www.scopus.com/inward/record.url?scp=0020076690&partnerID=8YFLogxK
U2 - 10.1093/geronj/37.2.161
DO - 10.1093/geronj/37.2.161
M3 - Article
C2 - 7057001
AN - SCOPUS:0020076690
SN - 0022-1422
VL - 37
SP - 161
EP - 168
JO - Journals of Gerontology
JF - Journals of Gerontology
IS - 2
ER -