Brain benzodiazepine levels following intravenous administration of [3H]diazepam: relationship to the potentiation of purinergic depression of central nervous system neurons

P. Skolnick, S. M. Paul, P. J. Marangos

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9 Scopus citations

Abstract

Levels of [3H]benzodiazepine were measured in rat cerebral cortex following intravenous injection of [3H]diazepam using a dose and time schedule reported to elicit a marked potentiation of the depressant effects of iontophoretically applied 5'-AMP to rat cerebral cortical neurons. The levels of [3H]benzodiazepine obtained strongly suggest (i) that blockade of adenosine uptake as a mechanism of this potentiation is not consistent with the potency of diazepam as an inhibitor of adensoine uptake in vitro, and (ii) that a potentiative interaction of adenosine and diazepam may reflect the binding of these compounds to benzodiazepine receptors.

Original languageEnglish
Pages (from-to)1040-1042
Number of pages3
JournalCanadian Journal of Physiology and Pharmacology
Volume57
Issue number9
DOIs
StatePublished - Jan 1 1979

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