Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Numerous methods of T cell depletion lead to impairment of learning and memory function in mice. While adoptive transfer of whole splenocytes rescues learning behavior impairments, the precise sub-population and antigenic specificity of the T cells mediating the rescue remains unknown. Using several transgenic mouse models in combination with adoptive transfers, we demonstrate the necessity of an antigen-specific CD4+ T cell compartment in normal spatial learning and memory, as measured by the Morris water maze (MWM). Moreover, transfer of a monoclonal T cell population reactive to the central nervous system (CNS) antigen, myelin oligodendrocyte glycoprotein (MOG), was sufficient to improve cognitive task performance in otherwise impaired OTII mice, raising the possibility that the antigen-specificity requirement of pro-cognitive T cells may be directed against CNS-derived self-antigens.

Original languageEnglish
Pages (from-to)58-63
Number of pages6
JournalBrain, Behavior, and Immunity
Volume35
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • 2D2 mice
  • Antigen specificity
  • CD4 T cells
  • Learning behavior
  • Meningeal immunity
  • Morris water maze
  • OTII mice
  • Pro-cognitive T cells

Fingerprint Dive into the research topics of 'Brain antigen-reactive CD4<sup>+</sup> T cells are sufficient to support learning behavior in mice with limited T cell repertoire'. Together they form a unique fingerprint.

Cite this