BRAF-MEK inhibitors as steroid-sparing bridge prior to checkpoint blockade therapy in symptomatic intracranial melanoma

Research output: Contribution to journalArticlepeer-review

Abstract

The introduction of immune checkpoint blockade (ICB) and BRAF-MEK inhibitors has substantially improved outcomes in patients with metastatic melanoma. However, several challenging factors may hinder the efficacy of ICB in patients with symptomatic intracranial metastatic melanoma who are immunosuppressed due to the use of steroids prior to the administration of ICB. This has resulted in the exclusion of patients treated with high dose steroid at baseline from the majority of ICB clinical trials. In addition, despite the high efficacy of BRAF-MEK inhibitors in BRAF-mutant intracranial metastatic melanoma, most tumors will eventually progress. This demonstrates a gap in addressing the best management in such patients. Here, we present a case demonstrating our approach in this patient population.

Original languageEnglish
Article number0022
JournalMelanoma Management
Volume8
Issue number2
DOIs
StatePublished - Jun 2021

Keywords

  • BRAF-MEK
  • brain
  • immune checkpoint blockade
  • intracranial
  • ipilimumab
  • metastatic melanoma
  • nivolumab
  • steroids
  • symptomatic
  • targeted therapy

Fingerprint

Dive into the research topics of 'BRAF-MEK inhibitors as steroid-sparing bridge prior to checkpoint blockade therapy in symptomatic intracranial melanoma'. Together they form a unique fingerprint.

Cite this