BPH: Why Do Patients Fail Medical Therapy?

Zeynep G. Gul, Steven A. Kaplan

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Purpose of Review: In this article, we review why patients may fail medical therapy for benign prostatic hyperplasia (BPH) and by doing so, gain a better understanding of the disease process and how to optimize the care of these patients. Recent Findings: A growing body of literature has attempted to better characterize the various mechanisms by which patients develop BPH as well as identify predictors of disease progression and treatment failure. Summary: BPH is a heterogenous disease process. A more personalized approach to treatment, including patient selection for medical or surgical management, would allow us to optimize patient care.

Original languageEnglish
Article number40
JournalCurrent urology reports
Issue number7
StatePublished - Jul 1 2019


  • 5alpha-reductase inhibitors
  • Alpha-blockers
  • Benign prostatic hyperplasia
  • Clinical trial results
  • Medical therapy
  • Predictors of treatment failure


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