TY - JOUR
T1 - Bone morphogenetic protein use in anterior cervical spine surgery
T2 - A review of current Literature concerning indications, safety, and efficacy
AU - Crawford, Charles H.
AU - Buchowski, Jacob M.
PY - 2009/12
Y1 - 2009/12
N2 - The application of recombinant human bone morphogenetic protein in the anterior cervical spine is controversial. Although recombinant human bone morphogenetic protein has been shown to produce fusion rates as high and likely higher than the "gold standard" autogenous iliac crest and fibula grafts (especially for multilevel fusions), complications associated with its use have been reported. These have included hematoma or seroma formation requiring repeat surgery, severe dysphagia, and anterior neck swelling requiring prolonged hospitalization and treatment. Although it is likely that with appropriate dosage, carrier, placement, and containment, the risk of these complications is not high, surgeons should be aware of the issues surrounding bone morphogenetic protein use in the cervical spine and must be prepared to prevent and/or manage the potentially life-threatening complications associated with its use.
AB - The application of recombinant human bone morphogenetic protein in the anterior cervical spine is controversial. Although recombinant human bone morphogenetic protein has been shown to produce fusion rates as high and likely higher than the "gold standard" autogenous iliac crest and fibula grafts (especially for multilevel fusions), complications associated with its use have been reported. These have included hematoma or seroma formation requiring repeat surgery, severe dysphagia, and anterior neck swelling requiring prolonged hospitalization and treatment. Although it is likely that with appropriate dosage, carrier, placement, and containment, the risk of these complications is not high, surgeons should be aware of the issues surrounding bone morphogenetic protein use in the cervical spine and must be prepared to prevent and/or manage the potentially life-threatening complications associated with its use.
KW - BMP
KW - Bone morphogenetic protein
KW - Cervical spine
KW - OP-1
KW - RhBMP-2
KW - RhBMP-7
UR - http://www.scopus.com/inward/record.url?scp=74949117074&partnerID=8YFLogxK
U2 - 10.1097/WNQ.0b013e3181bd5c55
DO - 10.1097/WNQ.0b013e3181bd5c55
M3 - Review article
AN - SCOPUS:74949117074
SN - 1050-6438
VL - 19
SP - 283
EP - 287
JO - Neurosurgery Quarterly
JF - Neurosurgery Quarterly
IS - 4
ER -