Bone morphogenetic protein-7 in growth-plate chondrocytes: Regulation by retinoic acid is dependent on the stage of chondrocyte maturation

C. D. Grimsrud, R. N. Rosier, J. E. Puzas, P. R. Reynolds, S. D. Reynolds, D. G. Hicks, R. J. O'Keefe

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The expression of bone morphogenetic protein-7 was examined in chick growth-plate chondrocyte cultures. Low basal levels of bone morphogenetic protein-7 mRNA and protein expression were stimulated by increasing doses of all-trans retinoic acid, a metabolite of vitamin A. Data obtained support a role for bone morphogenetic protein-7 as an autocrine regulator of chondrocyte maturation in the growth plate. Regulation of bone morphogenetic protein-7 by retinoic acid may be important in normal growth and development as well as pathologic conditions of an excess or deficiency of vitamin A.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalJournal of Orthopaedic Research
Volume16
Issue number2
DOIs
StatePublished - 1998

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