Bone metastasis: An update on mechanisms of bone resorption and therapeutic strategies

Regis J. O'Keefe, Edward M. Schwarz, Brendan F. Boyce

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Bone metastasis is a leading cause of morbidity in cancer patients. Bone metastasis involves a complex series of biologic events but is ultimately dependent on cancer-mediated bone resorption. Recent advances have established a critical role for resident osteoclasts in this process. Furthermore, the paracrine interactions between cancer cells, resident stromal cells and osteoblasts, and cells in the osteoclast lineage have been defined along with the biologic mediators of these important interactions. These advances have provided novel targets to inhibit tumor-mediated bone resorption and have the potential to markedly decrease the morbidity of terminal cancer. (C) 2000 Lippincott Williams and Wilkins, Inc.

Original languageEnglish
Pages (from-to)353-359
Number of pages7
JournalCurrent Opinion in Orthopaedics
Volume11
Issue number5
DOIs
StatePublished - Oct 14 2000
Externally publishedYes

Fingerprint Dive into the research topics of 'Bone metastasis: An update on mechanisms of bone resorption and therapeutic strategies'. Together they form a unique fingerprint.

  • Cite this