TY - JOUR
T1 - Bone-immune cell crosstalk
T2 - Bone diseases
AU - Mori, Giorgio
AU - D'Amelio, Patrizia
AU - Faccio, Roberta
AU - Brunetti, Giacomina
N1 - Publisher Copyright:
Copyright © 2015 Giorgio Mori et al.
PY - 2015
Y1 - 2015
N2 - Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incompletely understood. This review aims to shed new lights into the mechanisms of bone diseases involving immune cells. In particular, we focused our attention on the major pathogenic mechanism underlying periodontal disease, psoriatic arthritis, postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, metastatic solid tumors, and multiple myeloma.
AB - Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incompletely understood. This review aims to shed new lights into the mechanisms of bone diseases involving immune cells. In particular, we focused our attention on the major pathogenic mechanism underlying periodontal disease, psoriatic arthritis, postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, metastatic solid tumors, and multiple myeloma.
UR - http://www.scopus.com/inward/record.url?scp=84929340004&partnerID=8YFLogxK
U2 - 10.1155/2015/108451
DO - 10.1155/2015/108451
M3 - Review article
C2 - 26000310
AN - SCOPUS:84929340004
SN - 2314-8861
VL - 2015
JO - Journal of Immunology Research
JF - Journal of Immunology Research
M1 - 108451
ER -