Bone health in children with recurrent and chronic pancreatitis: A multi-center cross sectional analysis

Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC); Maisam Abu-El-Haija; Lindsey Hornung; Kate Ellery; Douglas S. Fishman; Tanja Y. Gonska; Cheryl Gariepy; Mark Lowe; Katie Larson Ode; Asim Maqbool; Maria Mascarenhas; Veronique D. Morinville; Chee Y. Ooi; Emily R. Perito; Sarah Jane Schwarzenberg; Zachary M. Sellers; Babette S. Zemel; Ying Yuan; Fuchenchu Wang; Aliye Uc; Heidi J. Kalkwarf

doi:10.1016/j.pan.2023.08.006

Bone health in children with recurrent and chronic pancreatitis: A multi-center cross sectional analysis

Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC), Maisam Abu-El-Haija, Lindsey Hornung, Kate Ellery, Douglas S. Fishman, Tanja Y. Gonska, Cheryl Gariepy, Mark Lowe, Katie Larson Ode, Asim Maqbool, Maria Mascarenhas, Veronique D. Morinville, Chee Y. Ooi, Emily R. Perito, Sarah Jane Schwarzenberg, Zachary M. Sellers, Babette S. Zemel, Ying Yuan, Fuchenchu Wang, Aliye UcHeidi J. Kalkwarf

Research output: Contribution to journal › Article › peer-review

Abstract

Background/objectives: Bone health of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) is not well studied. Methods: This retrospective study was performed at three sites and included data from INSPPIRE-2. Results: Of the 87 children in the study: 46 had ARP (53%), 41 had CP (47%). Mean age was 13.6 ± 3.9 years at last DXA scan. The prevalence of low height-for-age (Z-score < −2) (13%, 10/78) and low bone mineral density (BMD) adjusted for height (Z-score < −2) (6.4%, 5/78) were higher than a healthy reference sample (2.5%, p < 0.0001 and p = 0.03, respectively). Conclusion: Children with ARP or CP have lower height and BMD than healthy peers. Attention to deficits in growth and bone mineral accrual in children with pancreatic disease is warranted.

Original language	English
Pages (from-to)	755-760
Number of pages	6
Journal	Pancreatology
Volume	23
Issue number	7
DOIs	https://doi.org/10.1016/j.pan.2023.08.006
State	Published - Nov 2023

Keywords

Bone health
Children
Pancreatitis

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Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC), Abu-El-Haija, M., Hornung, L., Ellery, K., Fishman, D. S., Gonska, T. Y., Gariepy, C., Lowe, M., Larson Ode, K., Maqbool, A., Mascarenhas, M., Morinville, V. D., Ooi, C. Y., Perito, E. R., Schwarzenberg, S. J., Sellers, Z. M., Zemel, B. S., Yuan, Y., Wang, F., ... Kalkwarf, H. J. (2023). Bone health in children with recurrent and chronic pancreatitis: A multi-center cross sectional analysis. Pancreatology, 23(7), 755-760. https://doi.org/10.1016/j.pan.2023.08.006

@article{b1272ba10bb54c678990719f0ffa193b,

title = "Bone health in children with recurrent and chronic pancreatitis: A multi-center cross sectional analysis",

abstract = "Background/objectives: Bone health of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) is not well studied. Methods: This retrospective study was performed at three sites and included data from INSPPIRE-2. Results: Of the 87 children in the study: 46 had ARP (53%), 41 had CP (47%). Mean age was 13.6 ± 3.9 years at last DXA scan. The prevalence of low height-for-age (Z-score < −2) (13%, 10/78) and low bone mineral density (BMD) adjusted for height (Z-score < −2) (6.4%, 5/78) were higher than a healthy reference sample (2.5%, p < 0.0001 and p = 0.03, respectively). Conclusion: Children with ARP or CP have lower height and BMD than healthy peers. Attention to deficits in growth and bone mineral accrual in children with pancreatic disease is warranted.",

keywords = "Bone health, Children, Pancreatitis",

author = "{Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)} and Maisam Abu-El-Haija and Lindsey Hornung and Kate Ellery and Fishman, {Douglas S.} and Gonska, {Tanja Y.} and Cheryl Gariepy and Mark Lowe and {Larson Ode}, Katie and Asim Maqbool and Maria Mascarenhas and Morinville, {Veronique D.} and Ooi, {Chee Y.} and Perito, {Emily R.} and Schwarzenberg, {Sarah Jane} and Sellers, {Zachary M.} and Zemel, {Babette S.} and Ying Yuan and Fuchenchu Wang and Aliye Uc and Kalkwarf, {Heidi J.}",

note = "Publisher Copyright: {\textcopyright} 2023 IAP and EPC",

year = "2023",

month = nov,

doi = "10.1016/j.pan.2023.08.006",

language = "English",

volume = "23",

pages = "755--760",

journal = "Pancreatology",

issn = "1424-3903",

number = "7",

}

Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC), Abu-El-Haija, M, Hornung, L, Ellery, K, Fishman, DS, Gonska, TY, Gariepy, C, Lowe, M, Larson Ode, K, Maqbool, A, Mascarenhas, M, Morinville, VD, Ooi, CY, Perito, ER, Schwarzenberg, SJ, Sellers, ZM, Zemel, BS, Yuan, Y, Wang, F, Uc, A & Kalkwarf, HJ 2023, 'Bone health in children with recurrent and chronic pancreatitis: A multi-center cross sectional analysis', Pancreatology, vol. 23, no. 7, pp. 755-760. https://doi.org/10.1016/j.pan.2023.08.006

TY - JOUR

T1 - Bone health in children with recurrent and chronic pancreatitis

T2 - A multi-center cross sectional analysis

AU - Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)

AU - Abu-El-Haija, Maisam

AU - Hornung, Lindsey

AU - Ellery, Kate

AU - Fishman, Douglas S.

AU - Gonska, Tanja Y.

AU - Gariepy, Cheryl

AU - Lowe, Mark

AU - Larson Ode, Katie

AU - Maqbool, Asim

AU - Mascarenhas, Maria

AU - Morinville, Veronique D.

AU - Ooi, Chee Y.

AU - Perito, Emily R.

AU - Schwarzenberg, Sarah Jane

AU - Sellers, Zachary M.

AU - Zemel, Babette S.

AU - Yuan, Ying

AU - Wang, Fuchenchu

AU - Uc, Aliye

AU - Kalkwarf, Heidi J.

PY - 2023/11

Y1 - 2023/11

N2 - Background/objectives: Bone health of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) is not well studied. Methods: This retrospective study was performed at three sites and included data from INSPPIRE-2. Results: Of the 87 children in the study: 46 had ARP (53%), 41 had CP (47%). Mean age was 13.6 ± 3.9 years at last DXA scan. The prevalence of low height-for-age (Z-score < −2) (13%, 10/78) and low bone mineral density (BMD) adjusted for height (Z-score < −2) (6.4%, 5/78) were higher than a healthy reference sample (2.5%, p < 0.0001 and p = 0.03, respectively). Conclusion: Children with ARP or CP have lower height and BMD than healthy peers. Attention to deficits in growth and bone mineral accrual in children with pancreatic disease is warranted.

AB - Background/objectives: Bone health of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) is not well studied. Methods: This retrospective study was performed at three sites and included data from INSPPIRE-2. Results: Of the 87 children in the study: 46 had ARP (53%), 41 had CP (47%). Mean age was 13.6 ± 3.9 years at last DXA scan. The prevalence of low height-for-age (Z-score < −2) (13%, 10/78) and low bone mineral density (BMD) adjusted for height (Z-score < −2) (6.4%, 5/78) were higher than a healthy reference sample (2.5%, p < 0.0001 and p = 0.03, respectively). Conclusion: Children with ARP or CP have lower height and BMD than healthy peers. Attention to deficits in growth and bone mineral accrual in children with pancreatic disease is warranted.

KW - Bone health

KW - Children

KW - Pancreatitis

UR - http://www.scopus.com/inward/record.url?scp=85171323589&partnerID=8YFLogxK

U2 - 10.1016/j.pan.2023.08.006

DO - 10.1016/j.pan.2023.08.006

M3 - Article

C2 - 37723006

AN - SCOPUS:85171323589

SN - 1424-3903

VL - 23

SP - 755

EP - 760

JO - Pancreatology

JF - Pancreatology

IS - 7

ER -

Bone health in children with recurrent and chronic pancreatitis: A multi-center cross sectional analysis

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Keywords

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