Bone collagen aggregation abnormalities in osteogenesis imperfecta

Steven L. Teitelbaum; William J. Kraft; Robert Lang; Louis V. Avioli

doi:10.1007/BF02547215

Bone collagen aggregation abnormalities in osteogenesis imperfecta

Steven L. Teitelbaum, William J. Kraft, Robert Lang, Louis V. Avioli

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Abstract

Scanning electron microscopy of bone collagen of three patients with osteogenesis imperfecta congenita demonstrates the failure of thin collagen fibers to aggregate extracellularly into the distinct and separately discernible large collagen fiber bundles of normal bone. These organizational alterations may in part explain the changes in physical properties which result in the frequent fractures characterizing this disease.

Original language	English
Pages (from-to)	75-79
Number of pages	5
Journal	Calcified Tissue Research
Volume	17
Issue number	1
DOIs	https://doi.org/10.1007/BF02547215
State	Published - Dec 1 1974

Keywords

Bone
Collagen
Osteogenesis Imperfecta

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10.1007/BF02547215

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title = "Bone collagen aggregation abnormalities in osteogenesis imperfecta",

abstract = "Scanning electron microscopy of bone collagen of three patients with osteogenesis imperfecta congenita demonstrates the failure of thin collagen fibers to aggregate extracellularly into the distinct and separately discernible large collagen fiber bundles of normal bone. These organizational alterations may in part explain the changes in physical properties which result in the frequent fractures characterizing this disease.",

keywords = "Bone, Collagen, Osteogenesis Imperfecta",

author = "Teitelbaum, {Steven L.} and Kraft, {William J.} and Robert Lang and Avioli, {Louis V.}",

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AU - Teitelbaum, Steven L.

AU - Kraft, William J.

AU - Lang, Robert

AU - Avioli, Louis V.

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Y1 - 1974/12/1

N2 - Scanning electron microscopy of bone collagen of three patients with osteogenesis imperfecta congenita demonstrates the failure of thin collagen fibers to aggregate extracellularly into the distinct and separately discernible large collagen fiber bundles of normal bone. These organizational alterations may in part explain the changes in physical properties which result in the frequent fractures characterizing this disease.

AB - Scanning electron microscopy of bone collagen of three patients with osteogenesis imperfecta congenita demonstrates the failure of thin collagen fibers to aggregate extracellularly into the distinct and separately discernible large collagen fiber bundles of normal bone. These organizational alterations may in part explain the changes in physical properties which result in the frequent fractures characterizing this disease.

KW - Bone

KW - Collagen

KW - Osteogenesis Imperfecta

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VL - 17

SP - 75

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JO - Calcified Tissue Research

JF - Calcified Tissue Research

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Bone collagen aggregation abnormalities in osteogenesis imperfecta

Abstract

Keywords

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