Scanning electron microscopy of bone collagen of three patients with osteogenesis imperfecta congenita demonstrates the failure of thin collagen fibers to aggregate extracellularly into the distinct and separately discernible large collagen fiber bundles of normal bone. These organizational alterations may in part explain the changes in physical properties which result in the frequent fractures characterizing this disease.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalCalcified Tissue Research
Issue number1
StatePublished - Dec 1 1974


  • Bone
  • Collagen
  • Osteogenesis Imperfecta


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