TY - JOUR
T1 - Body size from birth through adolescence in relation to risk of benign breast disease in young women
AU - Berkey, Catherine S.
AU - Rosner, Bernard
AU - Tamimi, Rulla M.
AU - Willett, Walter C.
AU - Hickey, Martha
AU - Toriola, Adetunji
AU - Frazier, A. Lindsay
AU - Colditz, Graham A.
N1 - Funding Information:
Supported by a Grant from The Breast Cancer Research Foundation (NYC, NY) to Dr. Colditz and by DK046834 from the National Institutes of Health (Bethesda, MD). Dr. Frazier was supported by an award from the American Institute for Cancer Research. Dr. Colditz, who founded GUTS, was supported, in part, by an American Cancer Society Clinical Research Professorship. The authors appreciate the ongoing, since 1996, dedication of our female GUTS participants and their mothers in NHSII.
Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Purpose: Body size, from birth throughout adulthood, is associated with breast cancer risk, but few studies have investigated early-life body size and benign breast disease (BBD), a well-established breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk. Methods: The Growing Up Today Study includes 9032 females who completed questionnaires annually from 1996 to 2001, then 2003, 2005, 2007, 2010, and 2013. In 1996, their mothers provided pregnancy-related data. From 2005 to 2013, participants (18 year+) reported whether they had ever been diagnosed with biopsy-confirmed BBD (N = 142 cases). Results: Girls had greater adiposity (BMI; kg/m2) at 10 year if they were larger at birth, if mother’s pre-pregnancy BMI was higher, or if gestational weight gain was greater (all p < .01). Maternal height was (positively) associated (p < .05) with adolescent peak height growth velocity (PHV; in./year). Greater 10 year adiposity was associated with lower PHV and less height growth 10–18 year (both p < .01). Adiposity at 10 year was inversely associated with BBD (OR 0.83/(kg/m2), p < .01) as was increasing adiposity 10–18 year (OR 0.85/(kg/m2), p = .01). In a separate model, 10 year height (OR 1.13/in., p = .02) and height growth 10–18 year (OR 1.19/in.; p < .01) were positively associated. PHV was similarly positively associated (OR 2.58, p = .01, fastest versus slowest growth quartiles). In a multivariable model of BBD risk, gestational weight gain (daughters at highest risk if <20 lb gained), PHV (slowest growing girls at lowest risk), age 10 year height (positive), and BMI (inverse) were the most critical childhood risk factors (each p < .05). Conclusions: Body size factors from pregnancy through adolescence were independently associated with BBD risk in young women.
AB - Purpose: Body size, from birth throughout adulthood, is associated with breast cancer risk, but few studies have investigated early-life body size and benign breast disease (BBD), a well-established breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk. Methods: The Growing Up Today Study includes 9032 females who completed questionnaires annually from 1996 to 2001, then 2003, 2005, 2007, 2010, and 2013. In 1996, their mothers provided pregnancy-related data. From 2005 to 2013, participants (18 year+) reported whether they had ever been diagnosed with biopsy-confirmed BBD (N = 142 cases). Results: Girls had greater adiposity (BMI; kg/m2) at 10 year if they were larger at birth, if mother’s pre-pregnancy BMI was higher, or if gestational weight gain was greater (all p < .01). Maternal height was (positively) associated (p < .05) with adolescent peak height growth velocity (PHV; in./year). Greater 10 year adiposity was associated with lower PHV and less height growth 10–18 year (both p < .01). Adiposity at 10 year was inversely associated with BBD (OR 0.83/(kg/m2), p < .01) as was increasing adiposity 10–18 year (OR 0.85/(kg/m2), p = .01). In a separate model, 10 year height (OR 1.13/in., p = .02) and height growth 10–18 year (OR 1.19/in.; p < .01) were positively associated. PHV was similarly positively associated (OR 2.58, p = .01, fastest versus slowest growth quartiles). In a multivariable model of BBD risk, gestational weight gain (daughters at highest risk if <20 lb gained), PHV (slowest growing girls at lowest risk), age 10 year height (positive), and BMI (inverse) were the most critical childhood risk factors (each p < .05). Conclusions: Body size factors from pregnancy through adolescence were independently associated with BBD risk in young women.
KW - Birth weight
KW - Childhood adiposity
KW - Gestational weight gain
KW - Height growth
KW - Maternal pre-pregnancy BMI
KW - Prenatal
UR - http://www.scopus.com/inward/record.url?scp=85008482343&partnerID=8YFLogxK
U2 - 10.1007/s10549-016-4084-5
DO - 10.1007/s10549-016-4084-5
M3 - Article
C2 - 28062981
AN - SCOPUS:85008482343
SN - 0167-6806
VL - 162
SP - 139
EP - 149
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 1
ER -