Body size and multiple myeloma mortality: A pooled analysis of 20 prospective studies

Lauren R. Teras; Cari M. Kitahara; Brenda M. Birmann; Patricia A. Hartge; Sophia S. Wang; Kim Robien; Alpa V. Patel; Hans Olov Adami; Elisabete Weiderpass; Graham G. Giles; Pramil N. Singh; Michael Alavanja; Laura E. Beane Freeman; Leslie Bernstein; Julie E. Buring; Graham A. Colditz; Gary E. Fraser; Susan M. Gapstur; J. Michael Gaziano; Edward Giovannucci; Jonathan N. Hofmann; Martha S. Linet; Gila Neta; Yikyung Park; Ulrike Peters; Philip S. Rosenberg; Catherine Schairer; Howard D. Sesso; Meir J. Stampfer; Kala Visvanathan; Emily White; Alicja Wolk; Anne Zeleniuch-Jacquotte; Amy Berrington de González; Mark P. Purdue

doi:10.1111/bjh.12935

Body size and multiple myeloma mortality: A pooled analysis of 20 prospective studies

Lauren R. Teras, Cari M. Kitahara, Brenda M. Birmann, Patricia A. Hartge, Sophia S. Wang, Kim Robien, Alpa V. Patel, Hans Olov Adami, Elisabete Weiderpass, Graham G. Giles, Pramil N. Singh, Michael Alavanja, Laura E. Beane Freeman, Leslie Bernstein, Julie E. Buring, Graham A. Colditz, Gary E. Fraser, Susan M. Gapstur, J. Michael Gaziano, Edward GiovannucciJonathan N. Hofmann, Martha S. Linet, Gila Neta, Yikyung Park, Ulrike Peters, Philip S. Rosenberg, Catherine Schairer, Howard D. Sesso, Meir J. Stampfer, Kala Visvanathan, Emily White, Alicja Wolk, Anne Zeleniuch-Jacquotte, Amy Berrington de González, Mark P. Purdue

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Abstract

Multiple myeloma (MM) is a rare but highly fatal malignancy. High body weight is associated with this cancer, but several questions remain regarding the aetiological relevance of timing and location of body weight. To address these questions, we conducted a pooled analysis of MM mortality using 1·5 million participants (including 1388 MM deaths) from 20 prospective cohorts in the National Cancer Institute Cohort Consortium. Proportional hazards regression was used to calculate pooled multivariate hazard ratios (HRs) and 95% confidence intervals (CIs). Associations with elevated MM mortality were observed for higher early-adult body mass index (BMI; HR = 1·22, 95% CI: 1·09-1·35 per 5 kg/m²) and for higher cohort-entry BMI (HR 1·09, 95% CI: 1·03-1·16 per 5 kg/m²) and waist circumference (HR = 1·06, 95% CI: 1·02-1·10 per 5 cm). Women who were the heaviest, both in early adulthood (BMI 25+) and at cohort entry (BMI 30+) were at greater risk compared to those with BMI 18·5 ≤ 25 at both time points (HR = 1·95, 95% CI: 1·33-2·86). Waist-to-hip ratio and height were not associated with MM mortality. These observations suggest that overall, and possibly also central, obesity influence myeloma mortality, and women have the highest risk of death from this cancer if they remain heavy throughout adulthood.

Original language	English
Pages (from-to)	667-676
Number of pages	10
Journal	British Journal of Haematology
Volume	166
Issue number	5
DOIs	https://doi.org/10.1111/bjh.12935
State	Published - Sep 2014

Keywords

And anthropometry
Body mass index
Multiple myeloma
Pooled analysis
Prospective cohort study

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Teras, L. R., Kitahara, C. M., Birmann, B. M., Hartge, P. A., Wang, S. S., Robien, K., Patel, A. V., Adami, H. O., Weiderpass, E., Giles, G. G., Singh, P. N., Alavanja, M., Beane Freeman, L. E., Bernstein, L., Buring, J. E., Colditz, G. A., Fraser, G. E., Gapstur, S. M., Gaziano, J. M., ... Purdue, M. P. (2014). Body size and multiple myeloma mortality: A pooled analysis of 20 prospective studies. British Journal of Haematology, 166(5), 667-676. https://doi.org/10.1111/bjh.12935

@article{ab7da95f4b154f9c9100eca21ae998a3,

title = "Body size and multiple myeloma mortality: A pooled analysis of 20 prospective studies",

abstract = "Multiple myeloma (MM) is a rare but highly fatal malignancy. High body weight is associated with this cancer, but several questions remain regarding the aetiological relevance of timing and location of body weight. To address these questions, we conducted a pooled analysis of MM mortality using 1·5 million participants (including 1388 MM deaths) from 20 prospective cohorts in the National Cancer Institute Cohort Consortium. Proportional hazards regression was used to calculate pooled multivariate hazard ratios (HRs) and 95% confidence intervals (CIs). Associations with elevated MM mortality were observed for higher early-adult body mass index (BMI; HR = 1·22, 95% CI: 1·09-1·35 per 5 kg/m2) and for higher cohort-entry BMI (HR 1·09, 95% CI: 1·03-1·16 per 5 kg/m2) and waist circumference (HR = 1·06, 95% CI: 1·02-1·10 per 5 cm). Women who were the heaviest, both in early adulthood (BMI 25+) and at cohort entry (BMI 30+) were at greater risk compared to those with BMI 18·5 ≤ 25 at both time points (HR = 1·95, 95% CI: 1·33-2·86). Waist-to-hip ratio and height were not associated with MM mortality. These observations suggest that overall, and possibly also central, obesity influence myeloma mortality, and women have the highest risk of death from this cancer if they remain heavy throughout adulthood.",

keywords = "And anthropometry, Body mass index, Multiple myeloma, Pooled analysis, Prospective cohort study",

author = "Teras, {Lauren R.} and Kitahara, {Cari M.} and Birmann, {Brenda M.} and Hartge, {Patricia A.} and Wang, {Sophia S.} and Kim Robien and Patel, {Alpa V.} and Adami, {Hans Olov} and Elisabete Weiderpass and Giles, {Graham G.} and Singh, {Pramil N.} and Michael Alavanja and {Beane Freeman}, {Laura E.} and Leslie Bernstein and Buring, {Julie E.} and Colditz, {Graham A.} and Fraser, {Gary E.} and Gapstur, {Susan M.} and Gaziano, {J. Michael} and Edward Giovannucci and Hofmann, {Jonathan N.} and Linet, {Martha S.} and Gila Neta and Yikyung Park and Ulrike Peters and Rosenberg, {Philip S.} and Catherine Schairer and Sesso, {Howard D.} and Stampfer, {Meir J.} and Kala Visvanathan and Emily White and Alicja Wolk and Anne Zeleniuch-Jacquotte and {de Gonz{\'a}lez}, {Amy Berrington} and Purdue, {Mark P.}",

year = "2014",

month = sep,

doi = "10.1111/bjh.12935",

language = "English",

volume = "166",

pages = "667--676",

journal = "British Journal of Haematology",

issn = "0007-1048",

number = "5",

}

Teras, LR, Kitahara, CM, Birmann, BM, Hartge, PA, Wang, SS, Robien, K, Patel, AV, Adami, HO, Weiderpass, E, Giles, GG, Singh, PN, Alavanja, M, Beane Freeman, LE, Bernstein, L, Buring, JE, Colditz, GA, Fraser, GE, Gapstur, SM, Gaziano, JM, Giovannucci, E, Hofmann, JN, Linet, MS, Neta, G, Park, Y, Peters, U, Rosenberg, PS, Schairer, C, Sesso, HD, Stampfer, MJ, Visvanathan, K, White, E, Wolk, A, Zeleniuch-Jacquotte, A, de González, AB & Purdue, MP 2014, 'Body size and multiple myeloma mortality: A pooled analysis of 20 prospective studies', British Journal of Haematology, vol. 166, no. 5, pp. 667-676. https://doi.org/10.1111/bjh.12935

TY - JOUR

T1 - Body size and multiple myeloma mortality

T2 - A pooled analysis of 20 prospective studies

AU - Teras, Lauren R.

AU - Kitahara, Cari M.

AU - Birmann, Brenda M.

AU - Hartge, Patricia A.

AU - Wang, Sophia S.

AU - Robien, Kim

AU - Patel, Alpa V.

AU - Adami, Hans Olov

AU - Weiderpass, Elisabete

AU - Giles, Graham G.

AU - Singh, Pramil N.

AU - Alavanja, Michael

AU - Beane Freeman, Laura E.

AU - Bernstein, Leslie

AU - Buring, Julie E.

AU - Colditz, Graham A.

AU - Fraser, Gary E.

AU - Gapstur, Susan M.

AU - Gaziano, J. Michael

AU - Giovannucci, Edward

AU - Hofmann, Jonathan N.

AU - Linet, Martha S.

AU - Neta, Gila

AU - Park, Yikyung

AU - Peters, Ulrike

AU - Rosenberg, Philip S.

AU - Schairer, Catherine

AU - Sesso, Howard D.

AU - Stampfer, Meir J.

AU - Visvanathan, Kala

AU - White, Emily

AU - Wolk, Alicja

AU - Zeleniuch-Jacquotte, Anne

AU - de González, Amy Berrington

AU - Purdue, Mark P.

PY - 2014/9

Y1 - 2014/9

N2 - Multiple myeloma (MM) is a rare but highly fatal malignancy. High body weight is associated with this cancer, but several questions remain regarding the aetiological relevance of timing and location of body weight. To address these questions, we conducted a pooled analysis of MM mortality using 1·5 million participants (including 1388 MM deaths) from 20 prospective cohorts in the National Cancer Institute Cohort Consortium. Proportional hazards regression was used to calculate pooled multivariate hazard ratios (HRs) and 95% confidence intervals (CIs). Associations with elevated MM mortality were observed for higher early-adult body mass index (BMI; HR = 1·22, 95% CI: 1·09-1·35 per 5 kg/m2) and for higher cohort-entry BMI (HR 1·09, 95% CI: 1·03-1·16 per 5 kg/m2) and waist circumference (HR = 1·06, 95% CI: 1·02-1·10 per 5 cm). Women who were the heaviest, both in early adulthood (BMI 25+) and at cohort entry (BMI 30+) were at greater risk compared to those with BMI 18·5 ≤ 25 at both time points (HR = 1·95, 95% CI: 1·33-2·86). Waist-to-hip ratio and height were not associated with MM mortality. These observations suggest that overall, and possibly also central, obesity influence myeloma mortality, and women have the highest risk of death from this cancer if they remain heavy throughout adulthood.

AB - Multiple myeloma (MM) is a rare but highly fatal malignancy. High body weight is associated with this cancer, but several questions remain regarding the aetiological relevance of timing and location of body weight. To address these questions, we conducted a pooled analysis of MM mortality using 1·5 million participants (including 1388 MM deaths) from 20 prospective cohorts in the National Cancer Institute Cohort Consortium. Proportional hazards regression was used to calculate pooled multivariate hazard ratios (HRs) and 95% confidence intervals (CIs). Associations with elevated MM mortality were observed for higher early-adult body mass index (BMI; HR = 1·22, 95% CI: 1·09-1·35 per 5 kg/m2) and for higher cohort-entry BMI (HR 1·09, 95% CI: 1·03-1·16 per 5 kg/m2) and waist circumference (HR = 1·06, 95% CI: 1·02-1·10 per 5 cm). Women who were the heaviest, both in early adulthood (BMI 25+) and at cohort entry (BMI 30+) were at greater risk compared to those with BMI 18·5 ≤ 25 at both time points (HR = 1·95, 95% CI: 1·33-2·86). Waist-to-hip ratio and height were not associated with MM mortality. These observations suggest that overall, and possibly also central, obesity influence myeloma mortality, and women have the highest risk of death from this cancer if they remain heavy throughout adulthood.

KW - And anthropometry

KW - Body mass index

KW - Multiple myeloma

KW - Pooled analysis

KW - Prospective cohort study

UR - http://www.scopus.com/inward/record.url?scp=84905966539&partnerID=8YFLogxK

U2 - 10.1111/bjh.12935

DO - 10.1111/bjh.12935

M3 - Article

C2 - 24861847

AN - SCOPUS:84905966539

SN - 0007-1048

VL - 166

SP - 667

EP - 676

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 5

ER -

Body size and multiple myeloma mortality: A pooled analysis of 20 prospective studies

Abstract

Keywords

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