TY - JOUR
T1 - Body mass index throughout adulthood, physical activity, and risk of multiple myeloma
T2 - A prospective analysis in three large cohorts
AU - Marinac, Catherine R.
AU - Birmann, Brenda M.
AU - Lee, I. Min
AU - Rosner, Bernard A.
AU - Townsend, Mary K.
AU - Giovannucci, Edward
AU - Rebbeck, Timothy R.
AU - Buring, Julie E.
AU - Colditz, Graham A.
N1 - Funding Information:
This study was funded in part by the National Institutes of Health (K07 CA115687, R01 CA127435, P01 CA87969, UM1 CA186107, UM1 CA167552, R25 CA203650, R01 CA149445, CA047988, HL043851, and HL080467) and the American Cancer Society (RSG-11-020-01-CNE and Clinical Research Professorship (GAC)), and institutional funds from the Dana Farber Cancer Institute. We also gratefully acknowledge data preparation assistance from M.V. Moorthy and programming assistance from Ms. Catherine Suppan and Ms. Kelsey Lapenas. Lastly, we would like to thank the participants and staff of the Health Professionals Follow-up Study, Nurses’ Health Study and Women’s Health Study for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. The authors assume full responsibility for analyses and interpretation of these data. The funding sources had no role in the design, collection, analysis, interpretation or reporting of the study described herein, or in the decision to submit for publication.
Publisher Copyright:
© 2018 Cancer Research UK.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Background: Obesity is the only known modifiable multiple myeloma (MM) risk factor. However, the influence of obesity in earlier or later adulthood and the role of other energy balance correlates in MM development are unclear. Methods: We leveraged repeatedly updated data from the Nurses' Health Study, Health Professionals Follow-up Study, and Women's Health Study cohorts to further explore energy balance measures in MM etiology. Exposures derived from questionnaires included young adult body mass index (BMI), cumulative average BMI, BMI change since young adulthood, and cumulative average physical activity and walking. We assessed MM risk related to those variables with Cox proportional hazard models. Results: We observed 575 incident MM cases in over five million person-years of follow-up across the cohorts. In pooled analyses, MM risk increased 17% per 5 kg/m2 increase in cumulative average BMI (95% confidence interval (CI): 1.05, 1.29) and 28% per 5 kg/m2 increase in young adult BMI (CI: 1.12, 1.47); adjustment for BMI change since young adulthood did not affect either association. BMI change since young adulthood and cumulative average physical activity and walking were not significantly associated with MM risk. Conclusions: These findings suggest that a high BMI in early and later adulthood are risk factors for MM.
AB - Background: Obesity is the only known modifiable multiple myeloma (MM) risk factor. However, the influence of obesity in earlier or later adulthood and the role of other energy balance correlates in MM development are unclear. Methods: We leveraged repeatedly updated data from the Nurses' Health Study, Health Professionals Follow-up Study, and Women's Health Study cohorts to further explore energy balance measures in MM etiology. Exposures derived from questionnaires included young adult body mass index (BMI), cumulative average BMI, BMI change since young adulthood, and cumulative average physical activity and walking. We assessed MM risk related to those variables with Cox proportional hazard models. Results: We observed 575 incident MM cases in over five million person-years of follow-up across the cohorts. In pooled analyses, MM risk increased 17% per 5 kg/m2 increase in cumulative average BMI (95% confidence interval (CI): 1.05, 1.29) and 28% per 5 kg/m2 increase in young adult BMI (CI: 1.12, 1.47); adjustment for BMI change since young adulthood did not affect either association. BMI change since young adulthood and cumulative average physical activity and walking were not significantly associated with MM risk. Conclusions: These findings suggest that a high BMI in early and later adulthood are risk factors for MM.
UR - http://www.scopus.com/inward/record.url?scp=85043397847&partnerID=8YFLogxK
U2 - 10.1038/s41416-018-0010-4
DO - 10.1038/s41416-018-0010-4
M3 - Article
C2 - 29527008
AN - SCOPUS:85043397847
VL - 118
SP - 1013
EP - 1019
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 7
ER -