TY - JOUR
T1 - Body mass index, effect modifiers, and risk of pancreatic cancer
T2 - A pooled study of seven prospective cohorts
AU - Jiao, Li
AU - Berrington De Gonzalez, Amy
AU - Hartge, Patricia
AU - Pfeiffer, Ruth M.
AU - Park, Yikyung
AU - Freedman, D. Michal
AU - Gail, Mitchell H.
AU - Alavanja, Michael C.R.
AU - Albanes, Demetrius
AU - Beane Freeman, Laura E.
AU - Chow, Wong Ho
AU - Huang, Wen Yi
AU - Hayes, Richard B.
AU - Hoppin, Jane A.
AU - Ji, Bu Tian
AU - Leitzmann, Michael F.
AU - Linet, Martha S.
AU - Meinhold, Cari L.
AU - Schairer, Catherine
AU - Schatzkin, Arthur
AU - Virtamo, Jarmo
AU - Weinstein, Stephanie J.
AU - Zheng, Wei
AU - Stolzenberg-Solomon, Rachael Z.
N1 - Funding Information:
Financial Support The funding source of this pooled analysis is the Intramural Research Program of the National Cancer Institute, Division of Cancer Epidemiology and Genetics; and National Institute of Environment Health Sciences, Epidemiology Branch, National Institutes of Health.
PY - 2010/8
Y1 - 2010/8
N2 - Objective: To investigate whether the positive association of body mass index (BMI, kg/m2) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes. Methods: In a pooled analysis of primary data of seven prospective cohorts including 458,070 men and 485,689 women, we identified 2,454 patients with incident pancreatic cancer during an average 6.9 years of follow-up. Cox proportional hazard regression models were used in data analysis. Results: In a random-effects meta-analysis, for every 5 kg/m2 increment in BMI, the summary relative risk (RR) was 1.06 (95% confidence interval (CI) 0.99-1.13) for men and 1.12 (95% CI 1.05-1.19) for women. The aggregate analysis showed that compared with normal weight (BMI: 18.5 to <25), the adjusted RR was 1.13 (95% CI 1.03-1.23) for overweight (BMI: 25 to <30) and 1.19 (95% CI 1.05-1.35) for obesity class I (BMI: 30 to <35). Tests of interactions of BMI effects by other risk factors were not statistically significant. Every 5 kg/m2 increment in BMI was associated with an increased risk of pancreatic cancer among never and former smokers, but not among current smokers (P-interaction = 0.08). Conclusion: The present evidence suggests that a high BMI is an independent risk factor of pancreatic cancer.
AB - Objective: To investigate whether the positive association of body mass index (BMI, kg/m2) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes. Methods: In a pooled analysis of primary data of seven prospective cohorts including 458,070 men and 485,689 women, we identified 2,454 patients with incident pancreatic cancer during an average 6.9 years of follow-up. Cox proportional hazard regression models were used in data analysis. Results: In a random-effects meta-analysis, for every 5 kg/m2 increment in BMI, the summary relative risk (RR) was 1.06 (95% confidence interval (CI) 0.99-1.13) for men and 1.12 (95% CI 1.05-1.19) for women. The aggregate analysis showed that compared with normal weight (BMI: 18.5 to <25), the adjusted RR was 1.13 (95% CI 1.03-1.23) for overweight (BMI: 25 to <30) and 1.19 (95% CI 1.05-1.35) for obesity class I (BMI: 30 to <35). Tests of interactions of BMI effects by other risk factors were not statistically significant. Every 5 kg/m2 increment in BMI was associated with an increased risk of pancreatic cancer among never and former smokers, but not among current smokers (P-interaction = 0.08). Conclusion: The present evidence suggests that a high BMI is an independent risk factor of pancreatic cancer.
KW - Body mass index
KW - Effect modification
KW - Pancreatic cancer
KW - Pooled analysis
KW - Prospective cohort
UR - http://www.scopus.com/inward/record.url?scp=77955713296&partnerID=8YFLogxK
U2 - 10.1007/s10552-010-9558-x
DO - 10.1007/s10552-010-9558-x
M3 - Article
C2 - 20383573
AN - SCOPUS:77955713296
SN - 0957-5243
VL - 21
SP - 1305
EP - 1314
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 8
ER -