Body fluid compartment changes following cardiopulmonary bypass in dogs

Peter B. Manning, Ross A. Morgan, Arnold G. Coran, Theodore Z. Polley, Robert A. Drongowski, John T. Buckley, Douglas M. Behrendt

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

To investigate whether pulsatile perfusion affects postoperative edema, we examined weight, total body water (TBW), and extracellular fluid (ECF) following cardiopulmonary bypass (CPB) in dogs using three different perfusion systems. Fourteen dogs were divided into three groups differing only in the perfusion system used: Sarns nonpulsatile and pulsatile roller pumps and a University of Texas pulsatile pump. Weight, TBW, and ECF were measured preoperatively and on postoperative days (POD) 1, 3, and 7. No significant differences were seen in body weight, TBW, or ECF between groups. Body TBW (percent of body weight) rose significantly (P=0.005) to 72% on POD 3 and 7. ECF (percent of body weight) rose to 58% by POD 7 (P=0.008). These three perfusion systems produced no differences in the pattern of postoperative body fluid distribution after CPB, suggesting that there is no advantage to pulsatile perfusion for the purpose of decreasing postoperative edema.

Original languageEnglish
Pages (from-to)351-353
Number of pages3
JournalPediatric Surgery International
Volume3
Issue number5
DOIs
StatePublished - Jul 1 1988

Keywords

  • Body fluid compartments
  • Cardiopulmonary bypass
  • Perfusion systems TBW (percent of body weight) rose significantly

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    Manning, P. B., Morgan, R. A., Coran, A. G., Polley, T. Z., Drongowski, R. A., Buckley, J. T., & Behrendt, D. M. (1988). Body fluid compartment changes following cardiopulmonary bypass in dogs. Pediatric Surgery International, 3(5), 351-353. https://doi.org/10.1007/BF00189175