Cavitation is thought to be one mechanism for vessel rupture during shock wave lithotripsy treatment. However, just how cavitation induces vessel rupture remains unknown. In this work, a high-speed photomicrography system was set up to directly observe the dynamics of bubbles inside blood vessels in ex vivo rat mesenteries. Vascular rupture correlating to observed bubble dynamics were examined by imaging bubble extravasation and dye leakage. The high-speed images show that bubble expansion can cause vessel distention, and bubble collapse can lead to vessel invagination. Liquid jets were also observed to form. Our results suggest that all three mechanisms, vessel distention, invagination and liquid jets, can contribute to vessel rupture.

Original languageEnglish
Pages (from-to)321-326
Number of pages6
JournalUrological Research
Issue number4
StatePublished - Aug 2010


  • Cavitation
  • High-speed imaging
  • Vessel rupture


Dive into the research topics of 'Blood vessel rupture by cavitation'. Together they form a unique fingerprint.

Cite this