Blood vessel deformations on microsecond time scales by ultrasonic cavitation

Hong Chen, Wayne Kreider, Andrew A. Brayman, Michael R. Bailey, Thomas J. Matula

Research output: Contribution to journalArticlepeer-review

235 Scopus citations


Transient interactions among ultrasound, microbubbles, and microvessels were studied using high-speed photomicrography. We observed liquid jets, vessel distention (motion outward against the surrounding tissue), and vessel invagination (motion inward toward the lumen). Contrary to current paradigms, liquid jets were directed away from the nearest vessel wall and invagination exceeded distention. These observations provide insight into the mechanics of bubble-vessel interactions, which appear to depend qualitatively upon the mechanical properties of biological tissues.

Original languageEnglish
Article number034301
JournalPhysical Review Letters
Issue number3
StatePublished - Jan 18 2011


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