TY - JOUR
T1 - Blood pool agent strongly improves 3D magnetic resonance coronary angiography using an inversion pre-pulse
AU - Hofman, Mark B.M.
AU - Henson, Robert E.
AU - Kovács, Sándor J.
AU - Fischer, Stefan E.
AU - Lauffer, Randall B.
AU - Adzamli, Kofi
AU - De Becker, Jan
AU - Wickline, Samuel A.
AU - Lorenz, Christine H.
PY - 1999
Y1 - 1999
N2 - The ability of a blood pool contrast agent to enhance MR coronary angiography was defined. The proximal coronary vessels of pigs were imaged before and after administration of Gd-DTPA bound covalently to bovine serum albumin (0.2 mmol/kg). The contrast agent resulted in a reduction of the blood T1 value to 33 ± 5 msec, as determined in vivo with a Look-Locker technique. Both 2D and 3D imaging techniques were performed. An inversion pulse suppressed the signal of nonblood tissue postcontrast. After contrast agent administration, in the 3D data set the signal-to-noise ratio (SNR) of blood and contrast-to-noise ratio (CNR) of blood to myocardium were improved by factors of 2.0 ± 0.2 and 15 ± 8, respectively (P < 0.05). Postcontrast, the 3D acquisition was superior to the 2D technique in terms of spatial resolution, SNR of blood, and CNR of blood to myocardium. The high contrast of the 3D data set allowed for direct and rapid display of coronary arteries using a 'closest vessel projection'.
AB - The ability of a blood pool contrast agent to enhance MR coronary angiography was defined. The proximal coronary vessels of pigs were imaged before and after administration of Gd-DTPA bound covalently to bovine serum albumin (0.2 mmol/kg). The contrast agent resulted in a reduction of the blood T1 value to 33 ± 5 msec, as determined in vivo with a Look-Locker technique. Both 2D and 3D imaging techniques were performed. An inversion pulse suppressed the signal of nonblood tissue postcontrast. After contrast agent administration, in the 3D data set the signal-to-noise ratio (SNR) of blood and contrast-to-noise ratio (CNR) of blood to myocardium were improved by factors of 2.0 ± 0.2 and 15 ± 8, respectively (P < 0.05). Postcontrast, the 3D acquisition was superior to the 2D technique in terms of spatial resolution, SNR of blood, and CNR of blood to myocardium. The high contrast of the 3D data set allowed for direct and rapid display of coronary arteries using a 'closest vessel projection'.
KW - Blood pool contrast agent
KW - Coronary angiography
KW - Magnetic resonance imaging
KW - Swine
UR - http://www.scopus.com/inward/record.url?scp=0033005781&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1522-2594(199902)41:2<360::AID-MRM21>3.0.CO;2-C
DO - 10.1002/(SICI)1522-2594(199902)41:2<360::AID-MRM21>3.0.CO;2-C
M3 - Article
C2 - 10080285
AN - SCOPUS:0033005781
VL - 41
SP - 360
EP - 367
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 2
ER -