TY - JOUR
T1 - Blood lipid response to 20 weeks of supervised exercise in a large biracial population
T2 - The HERITAGE Family Study
AU - Leon, Arthur S.
AU - Rice, Treva
AU - Mandel, Stephen
AU - Despres, Jean Pierre
AU - Bergeron, Jean
AU - Gagnon, Jacques
AU - Rao, D. C.
AU - Skinner, James S.
AU - Wilmore, Jack H.
AU - Bouchard, Claude
N1 - Funding Information:
From the Laboratory of Physiological Hygiene and Exercise Science, Division of Kinesiology, University of Minnesota, Minneapolis, MN ; Division of Biostatistics, Washington University School of Medicine, St Louis, M; Physical Activity Sciences Laboratory, and Lipid Research Center Laval University Medical Center Laval University, Ste-Foy, Quebec, Canada ; Department of Kinesiology, Indiana University, Bloomington, IN; and Department of Health and Kinesiology, Texas A&M University, College Station, TX. Submitted June 25, 1999 ; accepted September 13, 1999 . Supported by National Heart, Lung, and Blood Institute Grants No . HL45670 (C.B.), HL47323 (A.S.L.), HL47317 (D.C.R.), HL47327 (J.S.S.), andHL47321(J.HW.). Address reprint requests to Arthur S. Leon, MD, H.L. Taylor Professor University of Minnesota, Division of Kinesiology, 202 Cooke Hall, 1900 University Ave SE, Minneapolis, MN 55455 . Copyright © 2000 by W.B. Saunders Company 0026-0495/00/4904-0020$10.00/0
Funding Information:
The University of Minnesota Clinical Research Center is supported by NIH Grant No . M1-RR000400 . C .B . is partially supported by the Donald E . Brown Research Chair on besity, and Arthur S . Leon is partially supported by the Henry L . Taylor Professorship in Exercise Science and Health Enhancement .
PY - 2000
Y1 - 2000
N2 - We studied the effects of 20 weeks of supervised cycle-ergometer exercise on plasma lipids in 675 healthy, sedentary, normolipidemic white and black men and women aged 17 to 65 years, participating in the HERITAGE Family Study. Fasting plasma lipids were assessed twice at baseline and 24 and 72 hours after the last exercise session and adjusted for plasma volume changes. No significant differences from the mean baseline levels were observed for total, low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) cholesterol and apolipoprotein B (Apo B). A significant reduction (P < .01) from baseline levels in plasma total and VLDL triglycerides was observed only in the 24-hour posttraining specimens, reflecting a response to the last bout of exercise. High-density lipoprotein (HDL) cholesterol increased 3.6% for the combined group, primarily due to an increase in HDL2, with an associated increase in Apo A-1 (P < .001). No significant differences were noted in the HDL response by sex, race, or age. An inverse correlation (r = -.241) was observed between the increase in HDL cholesterol and change in body fat only in men, and the increase in HDL cholesterol was unrelated to the change in maximal oxygen uptake (V̇2max). Copyright (C) 2000 by W. B. Saunders Company.
AB - We studied the effects of 20 weeks of supervised cycle-ergometer exercise on plasma lipids in 675 healthy, sedentary, normolipidemic white and black men and women aged 17 to 65 years, participating in the HERITAGE Family Study. Fasting plasma lipids were assessed twice at baseline and 24 and 72 hours after the last exercise session and adjusted for plasma volume changes. No significant differences from the mean baseline levels were observed for total, low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) cholesterol and apolipoprotein B (Apo B). A significant reduction (P < .01) from baseline levels in plasma total and VLDL triglycerides was observed only in the 24-hour posttraining specimens, reflecting a response to the last bout of exercise. High-density lipoprotein (HDL) cholesterol increased 3.6% for the combined group, primarily due to an increase in HDL2, with an associated increase in Apo A-1 (P < .001). No significant differences were noted in the HDL response by sex, race, or age. An inverse correlation (r = -.241) was observed between the increase in HDL cholesterol and change in body fat only in men, and the increase in HDL cholesterol was unrelated to the change in maximal oxygen uptake (V̇2max). Copyright (C) 2000 by W. B. Saunders Company.
UR - http://www.scopus.com/inward/record.url?scp=0034030972&partnerID=8YFLogxK
U2 - 10.1016/S0026-0495(00)80018-9
DO - 10.1016/S0026-0495(00)80018-9
M3 - Article
C2 - 10778878
AN - SCOPUS:0034030972
SN - 0026-0495
VL - 49
SP - 513
EP - 520
JO - Metabolism: clinical and experimental
JF - Metabolism: clinical and experimental
IS - 4
M1 - 80018
ER -