TY - JOUR
T1 - Blood lactate measurements and analysis during exercise
T2 - A guide for clinicians
AU - Goodwin, Matthew L.
AU - Harris, James E.
AU - Hernández, Andrés
AU - Gladden, L. Bruce
PY - 2007/7
Y1 - 2007/7
N2 - Blood lactate concentration ([La-]b) is one of the most often measured parameters during clinical exercise testing as well as during performance testing of athletes. While an elevated [La-]b may be indicative of ischemia or hypoxemia, it may also be a "normal" physiological response to exertion. In response to "all-out" maximal exertion lasting 30-120 seconds, peak [La-]b values of ∞15-25 mM may be observed 3-8 minutes postexercise. In response to progressive, incremental exercise, [La-]b increases gradually at frst and then more rapidly as the exercise becomes more intense. The work rate beyond which [La-]b increases exponentially [the lactate threshold. (LT)] is a better predictor of performance than VO2max and is a better indicator of exercise intensity than heart rate; thus LT (and other valid methods of describing this curvilinear [La-]b response with a single point) is useful in prescribing exercise intensities for most diseased and nondiseased patients alike. H+-monocarboxylate cotransporters provide the primary of three routes by which La-transport proceeds across the sarcolemma and red blood cell membrane. At rest and during most exercise conditions, whole blood [La-] values are on average 70% of the corresponding plasma [La-] values; thus when analyzing [La-]b, care should be taken to both (1) validate the [La-] b-measuring instrument with the criterion/reference enzymatic method and (2) interpret the results correctly based on what is being measured (plasma or whole blood). Overall, it is advantageous for clinicians to have a thorough understanding of [La-]b responses, blood La-transport and distribution, and [La-]b analysis.
AB - Blood lactate concentration ([La-]b) is one of the most often measured parameters during clinical exercise testing as well as during performance testing of athletes. While an elevated [La-]b may be indicative of ischemia or hypoxemia, it may also be a "normal" physiological response to exertion. In response to "all-out" maximal exertion lasting 30-120 seconds, peak [La-]b values of ∞15-25 mM may be observed 3-8 minutes postexercise. In response to progressive, incremental exercise, [La-]b increases gradually at frst and then more rapidly as the exercise becomes more intense. The work rate beyond which [La-]b increases exponentially [the lactate threshold. (LT)] is a better predictor of performance than VO2max and is a better indicator of exercise intensity than heart rate; thus LT (and other valid methods of describing this curvilinear [La-]b response with a single point) is useful in prescribing exercise intensities for most diseased and nondiseased patients alike. H+-monocarboxylate cotransporters provide the primary of three routes by which La-transport proceeds across the sarcolemma and red blood cell membrane. At rest and during most exercise conditions, whole blood [La-] values are on average 70% of the corresponding plasma [La-] values; thus when analyzing [La-]b, care should be taken to both (1) validate the [La-] b-measuring instrument with the criterion/reference enzymatic method and (2) interpret the results correctly based on what is being measured (plasma or whole blood). Overall, it is advantageous for clinicians to have a thorough understanding of [La-]b responses, blood La-transport and distribution, and [La-]b analysis.
KW - Lactate analyzers
KW - Lactate threshold
KW - Maximal lactate
KW - Onset of blood lactate accumulation
KW - Plasma
KW - Whole blood
UR - http://www.scopus.com/inward/record.url?scp=69249244706&partnerID=8YFLogxK
U2 - 10.1177/193229680700100414
DO - 10.1177/193229680700100414
M3 - Review article
C2 - 19885119
AN - SCOPUS:69249244706
SN - 1932-2968
VL - 1
SP - 558
EP - 569
JO - Journal of Diabetes Science and Technology
JF - Journal of Diabetes Science and Technology
IS - 4
ER -