Blood flow changes in human somatosensory cortex during anticipated stimulation

Wayne C. Drevets, Tom O. Videen, Marcus E. Raichle, Joseph R. Simpson, Harold Burtont, Abraham Z. Snyder

Research output: Contribution to journalLetter

247 Scopus citations

Abstract

POSITRON emission tomography (PET) measurements of brain blood flow were used to monitor changes in the human primary and secondary somatosensory cortices during the period when somatosensory stimuli were expected. In anticipation of either focal or innocuous touching, or localized, painful shocks, blood flow decreased in parts of the primary somatosensory cortex map located outside the representation of the skin area that was the target of the expected stimulus. Specifically, attending to an impending stimulus to the fingers produced a significant decrease in blood flow in the somatosensory zones for the face, whereas attending to stimulation of the toe produced decreases in the zones for the fingers and face. Decreases were more prominent in the side ipsilateral to the location of the expected stimulus. No significant changes in blood flow occurred in the region of the cortex representing the skin locus of the awaited stimulation. These results are concurrent with a model of spatial attention in which potential signal enhancement may rely on generalized suppression of background activity1.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalNature
Volume373
Issue number6511
DOIs
StatePublished - Jan 19 1995

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