Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice

Keyphrases

• Age of Onset 9%
• Alzheimer's Disease Model 100%
• Alzheimer's Disease Pathology 9%
• Alzheimer's Disease Risk 18%
• ApoE 100%
• ApoE Isoforms 9%
• APOE2 27%
• APOE4 63%
• Apolipoprotein E 100%
• APPswePS1dE9 100%
• Binding Motif 9%
• Co-accumulation 9%
• Differential Effects 9%
• Favorable Outcome 9%
• Future Therapies 9%
• Memory Deficits 9%
• Memory Impairment 9%
• Neuritic Plaques 9%
• Object Recognition 9%
• Pharmacological Inhibitors 9%
• Plaque 18%
• Protective Effect 9%
• Radial Arm Maze Test 9%
• Synthetic Peptides 9%
• Targeted Replacement 100%
• Targeted Replacement Mice 9%

Biochemistry, Genetics and Molecular Biology

• Allele 66%
• Amyloid Protein 16%
• Apolipoprotein E 100%
• Isoform 66%
• Mouse Model 100%
• Neuritic Plaques 16%
• Radial Arm Maze Test 16%

Neuroscience

• Alzheimer's Disease 50%
• Amnesia 16%
• Amyloid Protein 16%
• Apolipoprotein E 100%
• Memory Disorder 16%
• Oligomer 16%
• Radial Arm Maze 16%
• Senile Plaque 16%
• Synthetic Peptide 16%