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Blockade of IL-6R prevents preterm birth and adverse neonatal outcomes
Marcelo Farias-Jofre
, Roberto Romero
, Jose Galaz
, Yi Xu
, Derek Miller
, Valeria Garcia-Flores
, Marcia Arenas-Hernandez
, Andrew D. Winters
, Bruce A. Berkowitz
, Robert H. Podolsky
, Yimin Shen
, Tomi Kanninen
, Bogdan Panaitescu
, Catherine R. Glazier
, Roger Pique-Regi
, Kevin R. Theis
,
Nardhy Gomez-Lopez
Division of Clinical Research
DBBS - Molecular Cell Biology
Center of Regenerative Medicine
Institute of Clinical and Translational Sciences (ICTS)
DBBS - Computational and Systems Biology
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
DBBS - Immunology
Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs)
Research output
:
Contribution to journal
›
Article
›
peer-review
16
Scopus citations
Overview
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Keyphrases
Interleukin-1β
100%
Adverse Neonatal Outcome
100%
Interleukin-6 Receptor (IL-6R)
100%
Preterm Birth
100%
Intrauterine Inflammation
83%
Interleukin-6
33%
Neonatal Mortality
33%
Fisher's Exact Test
33%
Neurodevelopment
33%
Brain Oxidative Stress
33%
Prenatal Treatment
33%
IL-6 Blockade
33%
U-test
33%
Induced Preterm Birth
33%
Intra-amniotic Administration
33%
C57BL
16%
Murine Model
16%
Proteomics
16%
Inflammatory Process
16%
Microbiome
16%
Clinical Setting
16%
Children's Health
16%
Beneficial Effects
16%
Preterm Labor
16%
Maternal-fetal
16%
Biometrics
16%
Human Data
16%
Ultrasound-guided
16%
Single-cell RNA Sequencing (scRNA-seq)
16%
Elevated Concentrations
16%
Metagenomic Next-generation Sequencing (mNGS)
16%
Linear Mixed Model
16%
Maternal Health
16%
Fetal Brain
16%
Maternal Inflammation
16%
Common Pathway
16%
Intestinal Immune Homeostasis
16%
Transcriptomic Profiling
16%
Immunophenotyping
16%
Maternal-neonatal
16%
Neonatal Gut
16%
Perinatal Health
16%
Organ Inflammation
16%
Fetal Organs
16%
NICHD
16%
Alarmins
16%
Targeted Transcriptomics
16%
Neonatal Life
16%
Fetal Inflammation
16%
Amniotic Cavity
16%
Neonatal Inflammation
16%
Intra-amniotic Inflammatory Response
16%
Medicine and Dentistry
Premature Labor
100%
Interleukin 1
75%
Serositis
25%
Magnetic Resonance Imaging
25%
Gut
25%
Interleukin 6
25%
Oxidative Stress
25%
Fisher Exact Test
25%
Nerve Cell Differentiation
25%
Newborn Mortality
25%
Intra-Amniotic Drug Administration
25%
C57BL/6
12%
Homeostasis
12%
Child Health
12%
Biometry
12%
Microbiome
12%
Transcriptomics
12%
Small Cytoplasmic RNA
12%
Maternal Welfare
12%
Immunophenotyping
12%
Fetal Organ
12%
Alarmin
12%
Proteomics
12%