Blockade of 3-carbomethoxy-β-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216

Margaret Schweri; Michael Cain; James Cook; Steven Paul; Phil Skolnick

doi:10.1016/0091-3057(82)90304-5

Blockade of 3-carbomethoxy-β-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216

Margaret Schweri
, Michael Cain
, James Cook
, Steven Paul
, Phil Skolnick

School of Medicine

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

The benzodiazepine antagonists Ro 15-1788 and CGS 8216 blocked the clonic and tonic convulsions elicited by 3-carbomethoxy-β-carboline (β-CCM). The PD₅₀ values for Ro 15-1788, CGS 8216, and diazepam were: 2.0, 0.6, and 2.0 mg/kg, respectively. Neither Ro 15-1788 nor CGS 8216 potentiated the effect of a threshold convulsant dose of β-CCM. Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another β-carboline, harmaline. Diazepam, however, considerably reduced the tremorigenic actions of this drug.

Original language	English
Pages (from-to)	457-460
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(82)90304-5
State	Published - Sep 1982

Keywords

3-Carbomethoxy-β-carboline
Benzodiazepine antagonists
CGS 8216
Ro 15-1788

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10.1016/0091-3057(82)90304-5

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title = "Blockade of 3-carbomethoxy-β-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216",

abstract = "The benzodiazepine antagonists Ro 15-1788 and CGS 8216 blocked the clonic and tonic convulsions elicited by 3-carbomethoxy-β-carboline (β-CCM). The PD50 values for Ro 15-1788, CGS 8216, and diazepam were: 2.0, 0.6, and 2.0 mg/kg, respectively. Neither Ro 15-1788 nor CGS 8216 potentiated the effect of a threshold convulsant dose of β-CCM. Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another β-carboline, harmaline. Diazepam, however, considerably reduced the tremorigenic actions of this drug.",

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author = "Margaret Schweri and Michael Cain and James Cook and Steven Paul and Phil Skolnick",

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T1 - Blockade of 3-carbomethoxy-β-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216

AU - Schweri, Margaret

AU - Cain, Michael

AU - Cook, James

AU - Paul, Steven

AU - Skolnick, Phil

PY - 1982/9

Y1 - 1982/9

N2 - The benzodiazepine antagonists Ro 15-1788 and CGS 8216 blocked the clonic and tonic convulsions elicited by 3-carbomethoxy-β-carboline (β-CCM). The PD50 values for Ro 15-1788, CGS 8216, and diazepam were: 2.0, 0.6, and 2.0 mg/kg, respectively. Neither Ro 15-1788 nor CGS 8216 potentiated the effect of a threshold convulsant dose of β-CCM. Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another β-carboline, harmaline. Diazepam, however, considerably reduced the tremorigenic actions of this drug.

AB - The benzodiazepine antagonists Ro 15-1788 and CGS 8216 blocked the clonic and tonic convulsions elicited by 3-carbomethoxy-β-carboline (β-CCM). The PD50 values for Ro 15-1788, CGS 8216, and diazepam were: 2.0, 0.6, and 2.0 mg/kg, respectively. Neither Ro 15-1788 nor CGS 8216 potentiated the effect of a threshold convulsant dose of β-CCM. Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another β-carboline, harmaline. Diazepam, however, considerably reduced the tremorigenic actions of this drug.

KW - 3-Carbomethoxy-β-carboline

KW - Benzodiazepine antagonists

KW - CGS 8216

KW - Ro 15-1788

UR - https://www.scopus.com/pages/publications/0019963074

U2 - 10.1016/0091-3057(82)90304-5

DO - 10.1016/0091-3057(82)90304-5

M3 - Article

C2 - 6815667

AN - SCOPUS:0019963074

SN - 0091-3057

VL - 17

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JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

IS - 3

ER -

Blockade of 3-carbomethoxy-β-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216

Abstract

Keywords

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