Blockade of 3-carbomethoxy-β-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216

Margaret Schweri, Michael Cain, James Cook, Steven Paul, Phil Skolnick

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

The benzodiazepine antagonists Ro 15-1788 and CGS 8216 blocked the clonic and tonic convulsions elicited by 3-carbomethoxy-β-carboline (β-CCM). The PD50 values for Ro 15-1788, CGS 8216, and diazepam were: 2.0, 0.6, and 2.0 mg/kg, respectively. Neither Ro 15-1788 nor CGS 8216 potentiated the effect of a threshold convulsant dose of β-CCM. Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another β-carboline, harmaline. Diazepam, however, considerably reduced the tremorigenic actions of this drug.

Original languageEnglish
Pages (from-to)457-460
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume17
Issue number3
DOIs
StatePublished - Sep 1982
Externally publishedYes

Keywords

  • 3-Carbomethoxy-β-carboline
  • Benzodiazepine antagonists
  • CGS 8216
  • Ro 15-1788

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