TY - JOUR
T1 - Blockade of 3-carbomethoxy-β-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216
AU - Schweri, Margaret
AU - Cain, Michael
AU - Cook, James
AU - Paul, Steven
AU - Skolnick, Phil
PY - 1982/9
Y1 - 1982/9
N2 - The benzodiazepine antagonists Ro 15-1788 and CGS 8216 blocked the clonic and tonic convulsions elicited by 3-carbomethoxy-β-carboline (β-CCM). The PD50 values for Ro 15-1788, CGS 8216, and diazepam were: 2.0, 0.6, and 2.0 mg/kg, respectively. Neither Ro 15-1788 nor CGS 8216 potentiated the effect of a threshold convulsant dose of β-CCM. Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another β-carboline, harmaline. Diazepam, however, considerably reduced the tremorigenic actions of this drug.
AB - The benzodiazepine antagonists Ro 15-1788 and CGS 8216 blocked the clonic and tonic convulsions elicited by 3-carbomethoxy-β-carboline (β-CCM). The PD50 values for Ro 15-1788, CGS 8216, and diazepam were: 2.0, 0.6, and 2.0 mg/kg, respectively. Neither Ro 15-1788 nor CGS 8216 potentiated the effect of a threshold convulsant dose of β-CCM. Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another β-carboline, harmaline. Diazepam, however, considerably reduced the tremorigenic actions of this drug.
KW - 3-Carbomethoxy-β-carboline
KW - Benzodiazepine antagonists
KW - CGS 8216
KW - Ro 15-1788
UR - http://www.scopus.com/inward/record.url?scp=0019963074&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(82)90304-5
DO - 10.1016/0091-3057(82)90304-5
M3 - Article
C2 - 6815667
AN - SCOPUS:0019963074
SN - 0091-3057
VL - 17
SP - 457
EP - 460
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 3
ER -