@article{dc61dfc70d3646e6bbff45c1d196a8c5,
title = "Blending insights from implementation science and the social sciences to mitigate inequities in screening for hereditary cancer syndromes",
abstract = "Genomic screening to identify people at high risk for adult-onset hereditary conditions has potential to improve population health. However, if not equitably accessible, genomics-informed screening programs will exacerbate existing health inequities or give rise to new ones. To realize the disease prevention potential of these screening tools, we need strategies to broaden their reach. We propose a conceptual framework that merges insights from implementation science and sociological research on health inequities. Our framework does three things: first, it broadens the arenas of action beyond those typically addressed in implementation science frameworks; second, it argues for recruiting more diverse partners to share the work of implementation and dissemination; and third, it shows how implementation activities can be coordinated more effectively among those partners. We use screening for hereditary breast and ovarian cancers (HBOC) as a case to illustrate how this enhanced framework could guide implementation science and distribute the benefits of genomic medicine more equitably. Although our example is specific to genomics, this approach is more broadly applicable to the field of implementation science. Coordinated action among multiple stakeholders could translate a host of new technologies from the bench to the trench without creating new inequities or exacerbating existing ones.",
keywords = "Consolidated framework for implementation research, Genomics, Health inequities, Public health",
author = "Laura Senier and McBride, {Colleen M.} and Ramsey, {Alex T.} and Bonham, {Vence L.} and Chambers, {David A.}",
note = "Funding Information: Funding: The first author was supported in this work by the National Human Genome Research Institute of the National Institutes of Health, under award number 1K01HG006441-01A1; the third author was supported by the National Institute on Drug Abuse under award number K12DA041449; and the fourth author was supported [in part] by the Intramural Research Program of the National Human Genome Research Institute of the National Institutes of Health. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the National Cancer Institute, the National Institute of Drug Abuse, the National Human Genome Research Institute, or of the National Institutes of Health. Funding Information: Department of Sociology & Anthropology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA Department of Health Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA Department of Behavioral Sciences & Health Education, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA; colleen.marie.mcbride@emory.edu Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA; aramsey@wustl.edu Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA; bonhamv@mail.nih.gov Division of Cancer Control and Population Sciences, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850, USA; dchamber@mail.nih.gov Correspondence: l.senier@northeastern.edu; Tel.: +617-373-7482 Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2019",
month = oct,
day = "2",
doi = "10.3390/ijerph16203899",
language = "English",
volume = "16",
journal = "International Journal of Environmental Research and Public Health",
issn = "1661-7827",
number = "20",
}