Bladder Toxicity With Chronic Oral Cyclophosphamide Therapy in Nonmalignant Disease

Robert G. Aptekar, John P. Atkinson, John L. Decker, Sheldon M. Wolff, Elizabeth W. Chu

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Urinary bladder toxicity is a prominent toxic effect of cyclophosphamide. Over 600 months of oral cyclophosphamide has been given to 46 patients with SLE, Wegener's granulomatosis, RA, idiopathic nephrotic syndrome, and hypereosinophilic syndrome. Thirteen (28%) had urinary bladder complications. Three distinct problems were apparent: chronic cystitis in 6, abnormal urine cytology in 3, acute hemorrhagic cystitis in 4.These patterns could not have been segregated without urine cytology. Persistence of abnormal findings may lead to irreversible bladder toxicity.

Original languageEnglish
Pages (from-to)461-467
Number of pages7
JournalArthritis & Rheumatism
Volume16
Issue number4
DOIs
StatePublished - Jan 1 1973

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