TY - JOUR
T1 - Bladder Toxicity With Chronic Oral Cyclophosphamide Therapy in Nonmalignant Disease
AU - Aptekar, Robert G.
AU - Atkinson, John P.
AU - Decker, John L.
AU - Wolff, Sheldon M.
AU - Chu, Elizabeth W.
PY - 1973
Y1 - 1973
N2 - Urinary bladder toxicity is a prominent toxic effect of cyclophosphamide. Over 600 months of oral cyclophosphamide has been given to 46 patients with SLE, Wegener's granulomatosis, RA, idiopathic nephrotic syndrome, and hypereosinophilic syndrome. Thirteen (28%) had urinary bladder complications. Three distinct problems were apparent: chronic cystitis in 6, abnormal urine cytology in 3, acute hemorrhagic cystitis in 4.These patterns could not have been segregated without urine cytology. Persistence of abnormal findings may lead to irreversible bladder toxicity.
AB - Urinary bladder toxicity is a prominent toxic effect of cyclophosphamide. Over 600 months of oral cyclophosphamide has been given to 46 patients with SLE, Wegener's granulomatosis, RA, idiopathic nephrotic syndrome, and hypereosinophilic syndrome. Thirteen (28%) had urinary bladder complications. Three distinct problems were apparent: chronic cystitis in 6, abnormal urine cytology in 3, acute hemorrhagic cystitis in 4.These patterns could not have been segregated without urine cytology. Persistence of abnormal findings may lead to irreversible bladder toxicity.
UR - http://www.scopus.com/inward/record.url?scp=0015847894&partnerID=8YFLogxK
U2 - 10.1002/art.1780160405
DO - 10.1002/art.1780160405
M3 - Article
C2 - 4722431
AN - SCOPUS:0015847894
SN - 0004-3591
VL - 16
SP - 461
EP - 467
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
IS - 4
ER -