TY - JOUR
T1 - BK Channel Gating Mechanisms
T2 - Progresses Toward a Better Understanding of Variants Linked Neurological Diseases
AU - Cui, Jianmin
N1 - Funding Information:
The author would like to thank Jianhan Chen and Huanghe Yang for the critical reading of the manuscript. Guohui Zhang helped make the figures and format references.
Publisher Copyright:
Copyright © 2021 Cui.
PY - 2021/10/21
Y1 - 2021/10/21
N2 - The large conductance Ca2+-activated potassium (BK) channel is activated by both membrane potential depolarization and intracellular Ca2+ with distinct mechanisms. Neural physiology is sensitive to the function of BK channels, which is shown by the discoveries of neurological disorders that are associated with BK channel mutations. This article reviews the molecular mechanisms of BK channel activation in response to voltage and Ca2+ binding, including the recent progress since the publication of the atomistic structure of the whole BK channel protein, and the neurological disorders associated with BK channel mutations. These results demonstrate the unique mechanisms of BK channel activation and that these mechanisms are important factors in linking BK channel mutations to neurological disorders.
AB - The large conductance Ca2+-activated potassium (BK) channel is activated by both membrane potential depolarization and intracellular Ca2+ with distinct mechanisms. Neural physiology is sensitive to the function of BK channels, which is shown by the discoveries of neurological disorders that are associated with BK channel mutations. This article reviews the molecular mechanisms of BK channel activation in response to voltage and Ca2+ binding, including the recent progress since the publication of the atomistic structure of the whole BK channel protein, and the neurological disorders associated with BK channel mutations. These results demonstrate the unique mechanisms of BK channel activation and that these mechanisms are important factors in linking BK channel mutations to neurological disorders.
KW - activation
KW - BK channel
KW - calcium
KW - gain of function mutation
KW - loss of function mutation
KW - neurological disorders
KW - voltage
UR - http://www.scopus.com/inward/record.url?scp=85118665300&partnerID=8YFLogxK
U2 - 10.3389/fphys.2021.762175
DO - 10.3389/fphys.2021.762175
M3 - Review article
C2 - 34744799
AN - SCOPUS:85118665300
SN - 1664-042X
VL - 12
JO - Frontiers in Physiology
JF - Frontiers in Physiology
M1 - 762175
ER -