Bispecific Antibodies for the Treatment of Acute Myeloid Leukemia

Daniel G. Guy, Geoffrey L. Uy

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Purpose of review: Bispecific antibodies combine antigen recognition sites from two or more antibodies into a single construct allowing simultaneous binding to multiple targets. Bispecific antibodies exist which can redirect immune effector cells against acute myeloid leukemia (AML) targets. This review will highlight the progress to date and the challenges in developing bispecific antibodies for the treatment of AML. Recent findings: Currently, a number of bispecific antibody formats including bispecific T cell engagers, dual affinity retargeting proteins, and tandem diabodies are in clinical development for AML. These antibodies target antigens present on AML blasts, including CD33, and the low affinity IL3 receptor, CD123. T cell redirecting bispecific antibodies in early phase clinical trials for AML include AG330, flotetuzumab, JNJ-63709178, and AMV564. Summary: Bispecific antibodies represent a promising immunotherapeutic approach for the treatment of cancer. The results of ongoing studies in AML will elucidate the potential for these agents in AML.

Original languageEnglish
Pages (from-to)417-425
Number of pages9
JournalCurrent Hematologic Malignancy Reports
Volume13
Issue number6
DOIs
StatePublished - Dec 1 2018

Keywords

  • Acute myeloid leukemia
  • Bispecific T cell engager
  • Bispecific antibody
  • Dual affinity retargeting protein

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