@article{68dc9fdc083c4762b333d0837948a1c3,
title = "Birth with synthetic oxytocin and the risk of being overweight or obese during childhood",
abstract = "Background: Despite the importance of oxytocinergic signalling for satiety regulation and energy balance, the impact of exposure to synthetic oxytocin during childbirth on obesity during childhood remains unknown. Objectives: To examine the association between oxytocin exposure during labour and the risk of being overweight or obese during childhood. Methods: Synthetic oxytocin exposure data of mothers from the Danish Medical Birth Registry were linked with self-reported anthropometric data of their children from the Danish National Birth Cohort (5 months–11 years of age). Multinomial logistic regression and latent class growth analyses were performed to determine the association between oxytocin exposure and obesity during childhood. Results: With the exception of the normal weight-to-overweight group between ages 5 and 12 months, none of the other analyses revealed a significant association between synthetic oxytocin use and the risk of being overweight until the age of 11 years. Furthermore, latent class growth analysis did not reveal an association between oxytocin exposure at birth and the risk of being overweight or obese during childhood. Conclusions: Our analysis of a large cohort of children who varied in their synthetic oxytocin exposure status at childbirth did not reveal an association between oxytocin exposure and the risk of childhood overweight/obesity.",
keywords = "childbirth, labour, overweight, oxytocin exposure, oxytocin receptor, paediatric obesity",
author = "Arvind Palanisamy and Toftlund, {Sarah A.} and Tusar Giri and Katrine Strandberg-Larsen and L{\o}nfeldt, {Nicole N.}",
note = "Funding Information: The Danish National Birth Cohort was established with a significant grant from the Danish National Research Foundation. Additional support was obtained from the Danish Regional Committees, the Pharmacy Foundation, the Egmont Foundation, the March of Dimes Birth Defects Foundation, the Health Foundation and other minor grants. The DNBC Biobank has been supported by the Novo Nordisk Foundation and the Lundbeck Foundation. Follow-up of mothers and children have been supported by the Danish Medical Research Council (SSVF 0646, 271-08-0839/06-066023, O602-01042B, 0602-02738B), the Lundbeck Foundation (195/04, R100-A9193), The Innovation Fund Denmark 0603-00294B (09-067124), the Nordea Foundation (02-2013-2014), Aarhus Ideas (AU R9-A959-13-S804), University of Copenhagen Strategic Grant (IFSV 2012) and the Danish Council for Independent Research (DFF – 4183-00594 and DFF - 4183-00152). We would also like to thank Professor Claus Thorn Ekstr{\o}m, from the Section of Biostatistics, Department of Public Health, University of Copenhagen, for his advice and guidance on the latent class growth analysis. Funding Information: The Danish National Birth Cohort was established with a significant grant from the Danish National Research Foundation. Additional support was obtained from the Danish Regional Committees, the Pharmacy Foundation, the Egmont Foundation, the March of Dimes Birth Defects Foundation, the Health Foundation and other minor grants. The DNBC Biobank has been supported by the Novo Nordisk Foundation and the Lundbeck Foundation. Follow‐up of mothers and children have been supported by the Danish Medical Research Council (SSVF 0646, 271‐08‐0839/06‐066023, O602‐01042B, 0602‐02738B), the Lundbeck Foundation (195/04, R100‐A9193), The Innovation Fund Denmark 0603‐00294B (09‐067124), the Nordea Foundation (02‐2013‐2014), Aarhus Ideas (AU R9‐A959‐13‐S804), University of Copenhagen Strategic Grant (IFSV 2012) and the Danish Council for Independent Research (DFF – 4183‐00594 and DFF ‐ 4183‐00152). We would also like to thank Professor Claus Thorn Ekstr{\o}m, from the Section of Biostatistics, Department of Public Health, University of Copenhagen, for his advice and guidance on the latent class growth analysis. Funding Information: Danish Council for Independent Research Medical Sciences; University of Copenhagen, Grant/Award Number: IFSV 2012; Aarhus Ideas, Grant/Award Number: AU R9‐A959‐13‐S804; Nordea Foundation, Grant/Award Number: 02‐2013‐2014; Innovation Fund Denmark, Grant/Award Numbers: 09‐067124, 0603‐00294B; Lundbeck Foundation, Grant/Award Numbers: R100‐A9193, 195/04; Danish Medical Research Council, Grant/Award Numbers: DFF ‐ 4183‐00152, DFF – 4183‐00594, 0602‐02738B, O602‐01042B, 271‐08‐0839/06‐066023, SSVF 0646 Funding information Publisher Copyright: {\textcopyright} 2021 World Obesity Federation",
year = "2022",
month = apr,
doi = "10.1111/ijpo.12871",
language = "English",
volume = "17",
journal = "Pediatric Obesity",
issn = "2047-6302",
number = "4",
}