Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976

Janet W. Rich-Edwards, Meir J. Stampfer, Jo Ann E. Manson, Bernard Rosner, Susan E. Hankinson, Graham A. Colditz, Walter C. Willett, Charles H. Hennekens

Research output: Contribution to journalArticle

598 Scopus citations

Abstract

Objective: To examine the association between birth weight and non-fatal adult cardiovascular disease while controlling for potential confounders such as socioeconomic group and adult lifestyle, Design: Retrospective self report of birth weight in an ongoing longitudinal cohort of nurses followed up by postal questionnaire every two years. Setting: Nurses' health study, a cohort of 121 700 women followed up since 1976. Main outcome measures: Non-fatal cardiovascular disease, including myocardial infarction, coronary revascularisation, and stroke, Results: Among the 70 297 women free of cardiovascular disease at baseline who reported birth weight in the 1992 questionnaire there were 1309 first cases of non-fatal cardiovascular disease, Increasing birth weight was associated with decreasing risk of non-fatal cardiovascular disease. There were 1216 first cases of non-fatal cardiovascular disease among women who were singletons and had been born full term; their relative risks adjusted for several cardiovascular risk factors were 1.49 (95% confidence interval 1.05 to 2.10) for birth weight < 2268 g (< 5 lb 0 oz); 1.25 (0.98 to 1.61) for birth weight 2268-2495 g (5 lb 0 oz to 5 lb 8 oz); 1.12 (0.98 to 1.27) for birth weight > 2495-3175 g ( > 5 Ib 8 oz to 7 lb 0 oz); 1.00 (referent) for birth weight > 3175-3856 g(> 7 lb 0 oz to 8 lb 8 oz); 0.96 (0.80 to 1.15) for birth weight > 3856-4536 g (> 8 lb 8 oz to 10 lb 0 oz); and 0.68 (0.46 to 1.00) for birth weight > 4536 g ( > 10 lb 0 oz) (P value for trend = 0.0004). The inverse trend was apparent for both coronary heart disease and stroke. Conclusions: These data provide strong evidence of an association between birth weight and adult coronary heart disease and stroke.

Original languageEnglish
Pages (from-to)396-400
Number of pages5
JournalBritish Medical Journal
Volume315
Issue number7105
StatePublished - Aug 29 1997
Externally publishedYes

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    Rich-Edwards, J. W., Stampfer, M. J., Manson, J. A. E., Rosner, B., Hankinson, S. E., Colditz, G. A., Willett, W. C., & Hennekens, C. H. (1997). Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976. British Medical Journal, 315(7105), 396-400.