TY - JOUR
T1 - Birth by Caesarean section and otitis media in childhood
T2 - a retrospective cohort study
AU - Hartley, Maria
AU - Woolcott, Christy G.
AU - Langley, Joanne M.
AU - Brown, Mary M.
AU - Ashley-Martin, Jillian
AU - Kuhle, Stefan
N1 - Funding Information:
This work was supported by a Nova Scotia/Canadian Institutes of Health Research Regional Partnership Program Operating Grant (FRN #134531) with matching funds from the Dalhousie Medical Research Foundation, the IWK Health Centre Foundation, the Department of Obstetrics and Gynaecology Atlee Endowment Fund, and the Department of Pediatrics, IWK Health Centre, awarded to Dr. Stefan Kuhle. Maria Hartley received a Nova Scotia Graduate Scholarship from the Government of Nova Scotia. Joanne Langley holds the Canadian Institutes of Health Research - GlaxoSmithKline Chair in Pediatric Vaccinology. Mary Margaret Brown received a Nova Scotia Research and Innovation Graduate Scholarship from the Government of Nova Scotia and a Scotia Scholar Doctoral Award from the Nova Scotia Health Research Foundation. Portions of the data used in this report were made available by Health Data Nova Scotia of Dalhousie University. Although this research is based on data obtained from the Nova Scotia Department of Health and Wellness, the observations and opinions expressed are those of the authors and do not represent those of either Health Data Nova Scotia or the Department of Health and Wellness.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The objective of the present study was to examine the association between birth by Caesarean section (CS) and otitis media (OM) in childhood. We assembled a retrospective cohort of children born between 2003 and 2007 in Nova Scotia and followed them through to 2014. The cohort was derived through a linkage of the Nova Scotia Atlee Perinatal Database with provincial administrative health data. Cox proportional hazards, negative binomial regression and logistic regression were used to examine the association between CS and OM. Among the 36,318 children, 27% were born by CS, and 78% had at least one OM episode (median 2 episodes). Children born by CS were at a slightly higher risk of OM (hazard ratio 1.06, 95% confidence interval (CI) 1.03, 1.09), had more OM episodes in the first 7 years of life (incidence rate ratio 1.04, 95% CI 1.01, 1.07), and were more likely to be above the 95th percentile for OM episodes than children born vaginally (odds ratio 1.10, 95% CI 0.99, 1.23). Our study shows that birth by CS is weakly associated with OM in childhood, but the clinical and public health impact of these findings is small.
AB - The objective of the present study was to examine the association between birth by Caesarean section (CS) and otitis media (OM) in childhood. We assembled a retrospective cohort of children born between 2003 and 2007 in Nova Scotia and followed them through to 2014. The cohort was derived through a linkage of the Nova Scotia Atlee Perinatal Database with provincial administrative health data. Cox proportional hazards, negative binomial regression and logistic regression were used to examine the association between CS and OM. Among the 36,318 children, 27% were born by CS, and 78% had at least one OM episode (median 2 episodes). Children born by CS were at a slightly higher risk of OM (hazard ratio 1.06, 95% confidence interval (CI) 1.03, 1.09), had more OM episodes in the first 7 years of life (incidence rate ratio 1.04, 95% CI 1.01, 1.07), and were more likely to be above the 95th percentile for OM episodes than children born vaginally (odds ratio 1.10, 95% CI 0.99, 1.23). Our study shows that birth by CS is weakly associated with OM in childhood, but the clinical and public health impact of these findings is small.
UR - http://www.scopus.com/inward/record.url?scp=85082517044&partnerID=8YFLogxK
U2 - 10.1038/s41598-020-62229-y
DO - 10.1038/s41598-020-62229-y
M3 - Article
C2 - 32251348
AN - SCOPUS:85082517044
SN - 2045-2322
VL - 10
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 5219
ER -