TY - JOUR
T1 - Bipolar tumor-associated macrophages in ovarian cancer as targets for therapy
AU - Gupta, Vijayalaxmi
AU - Yull, Fiona
AU - Khabele, Dineo
N1 - Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/10
Y1 - 2018/10
N2 - Ovarian cancer, a rare but fatal disease, has been a challenging area in the field of gynecological cancer. Ovarian cancer is characterized by peritoneal metastasis, which is facilitated by a cross-talk between tumor cells and other cells in the tumor microenvironment (TME). In epithelial ovarian cancer, tumor-associated macrophages (TAMs) constitute over 50% of cells in the peritoneal TME and malignant ascites, and are potential targets for therapy. Here, we review the bipolar nature of TAMs and the evolving strategies to target TAMs in ovarian cancer.
AB - Ovarian cancer, a rare but fatal disease, has been a challenging area in the field of gynecological cancer. Ovarian cancer is characterized by peritoneal metastasis, which is facilitated by a cross-talk between tumor cells and other cells in the tumor microenvironment (TME). In epithelial ovarian cancer, tumor-associated macrophages (TAMs) constitute over 50% of cells in the peritoneal TME and malignant ascites, and are potential targets for therapy. Here, we review the bipolar nature of TAMs and the evolving strategies to target TAMs in ovarian cancer.
KW - Ovarian cancer
KW - Peritoneal metastasis
KW - Tumor microenvironment
KW - Tumor-associated macrophages
UR - http://www.scopus.com/inward/record.url?scp=85054515829&partnerID=8YFLogxK
U2 - 10.3390/cancers10100366
DO - 10.3390/cancers10100366
M3 - Review article
AN - SCOPUS:85054515829
SN - 2072-6694
VL - 10
JO - Cancers
JF - Cancers
IS - 10
M1 - 366
ER -