TY - JOUR
T1 - Biosystem design of Corynebacterium glutamicum for bioproduction
AU - Zha, Jian
AU - Zhao, Zhen
AU - Xiao, Zhengyang
AU - Eng, Thomas
AU - Mukhopadhyay, Aindrila
AU - Koffas, Mattheos AG
AU - Tang, Yinjie J.
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2023/2
Y1 - 2023/2
N2 - Corynebacterium glutamicum, a natural glutamate-producing bacterium adopted for industrial production of amino acids, has been extensively explored recently for high-level biosynthesis of amino acid derivatives, bulk chemicals such as organic acids and short-chain alcohols, aromatics, and natural products, including polyphenols and terpenoids. Here, we review the recent advances with a focus on biosystem design principles, metabolic characterization and modeling, omics analysis, utilization of nonmodel feedstock, emerging CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) tools for Corynebacterium strain engineering, biosensors, and novel strains of C. glutamicum. Future research directions for developing C. glutamicum cell factories are also discussed.
AB - Corynebacterium glutamicum, a natural glutamate-producing bacterium adopted for industrial production of amino acids, has been extensively explored recently for high-level biosynthesis of amino acid derivatives, bulk chemicals such as organic acids and short-chain alcohols, aromatics, and natural products, including polyphenols and terpenoids. Here, we review the recent advances with a focus on biosystem design principles, metabolic characterization and modeling, omics analysis, utilization of nonmodel feedstock, emerging CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) tools for Corynebacterium strain engineering, biosensors, and novel strains of C. glutamicum. Future research directions for developing C. glutamicum cell factories are also discussed.
UR - http://www.scopus.com/inward/record.url?scp=85144338861&partnerID=8YFLogxK
U2 - 10.1016/j.copbio.2022.102870
DO - 10.1016/j.copbio.2022.102870
M3 - Review article
C2 - 36549106
AN - SCOPUS:85144338861
SN - 0958-1669
VL - 79
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
M1 - 102870
ER -