TY - JOUR
T1 - Biosensors and their applications in microbial metabolic engineering
AU - Zhang, Fuzhong
AU - Keasling, Jay
N1 - Funding Information:
This work was supported in part by the Synthetic Biology Engineering Research Center, which is funded by National Science Foundation Award No. 0540879, and by the Joint BioEnergy Institute, which is funded by the U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research, through contract DE-AC02–05CH11231. F.Z. is supported by the Postdoctoral Fellowships Program of the Natural Sciences and Engineering Research Council of Canada.
PY - 2011/7
Y1 - 2011/7
N2 - Many metabolic pathways in microbial hosts have been created, modified and engineered to produce useful molecules. The titer and yield of a final compound is often limited by the inefficient use of cellular resources and imbalanced metabolism. Engineering sensory-regulation devices that regulate pathway gene expression in response to the environment and metabolic status of the cell have great potential to solve these problems, and enhance product titers and yields. This review will focus on recent developments in biosensor design, and their applications for controlling microbial behavior.
AB - Many metabolic pathways in microbial hosts have been created, modified and engineered to produce useful molecules. The titer and yield of a final compound is often limited by the inefficient use of cellular resources and imbalanced metabolism. Engineering sensory-regulation devices that regulate pathway gene expression in response to the environment and metabolic status of the cell have great potential to solve these problems, and enhance product titers and yields. This review will focus on recent developments in biosensor design, and their applications for controlling microbial behavior.
UR - http://www.scopus.com/inward/record.url?scp=79959913313&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2011.05.003
DO - 10.1016/j.tim.2011.05.003
M3 - Review article
C2 - 21664818
AN - SCOPUS:79959913313
SN - 0966-842X
VL - 19
SP - 323
EP - 329
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 7
ER -