Bioresorbable, wireless, passive sensors for continuous pH measurements and early detection of gastric leakage

Shuo Li, Di Lu, Shupeng Li, Jiaqi Liu, Yameng Xu, Ying Yan, Jorge Zárate Rodriguez, Hedan Bai, Raudel Avila, Shuming Kang, Xinchen Ni, Haiwen Luan, Hexia Guo, Wubin Bai, Changsheng Wu, Xuhao Zhou, Ziying Hu, Mitchell A. Pet, Chet W. Hammill, Matthew R. MacEwanWilson Z. Ray, Yonggang Huang, John A. Rogers

Research output: Contribution to journalArticlepeer-review


Continuous monitoring of biomarkers at locations adjacent to targeted internal organs can provide actionable information about postoperative status beyond conventional diagnostic methods. As an example, changes in pH in the intra-abdominal space after gastric surgeries can serve as direct indicators of potentially life-threatening leakage events, in contrast to symptomatic reactions that may delay treatment. Here, we report a bioresorbable, wireless, passive sensor that addresses this clinical need, designed to locally monitor pH for early detection of gastric leakage. A pH-responsive hydrogel serves as a transducer that couples to a mechanically optimized inductor-capacitor circuit for wireless readout. This platform enables real-time monitoring of pH with fast response time (within 1 hour) over a clinically relevant period (up to 7 days) and timely detection of simulated gastric leaks in animal models. These concepts have broad potential applications for temporary sensing of relevant biomarkers during critical risk periods following diverse types of surgeries.

Original languageEnglish
Article numbereadj0268
JournalScience Advances
Issue number16
StatePublished - 2024


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